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ProteomicsEffect of Ipomoeassin F on the Proteome Profile in Triple-Negative Breast Cancer Cells
Ipomoeassin F (Ipom-F) is a natural compound that exhibits a potent cytotoxic effect on triple-negative breast cancer (TNBC) cells. The mechanism underlying this selective potency remains unclear. To elucidate this mechanism, we analyzed the proteome profiles of the TNBC MDA-MB-231 cells after expos...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD060444 | Pride
Breast cancer Human Ipomoeassin f 
ProteomicsPhosphorylation of Cyclin F at Serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(Cyclin F) complex.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and cachexia often resulting in patient death within 3-5 years of diagnosis. Recently, we identified mutations to the CCNF gene, which encodes the Cyclin F protein, in c...
ORGANISM(S): Homo sapiens (Human) 
2017-12-08 | PXD004531 | Pride
Als Phosphorylation Ubiquitylation E3 ligase 
ProteomicsALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ
Recently, we identified missense mutations in CCNF that are causative of familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). CCNF encodes for cyclin F, a substrate recognition component of an E3-ubiquitin ligase. Mutations in CCNF directly implicates disrupti...
ORGANISM(S): Homo sapiens (Human) 
2021-03-18 | PXD014163 | Pride
Bioid Ubiquitylation Proteomics Amyotrophic lateral sclerosis Frontotemporal dementia Paraspeckles Cyclin f Rbm14 Homeostasis 
ProteomicsTMT-based quantitative proteomic analysis of Fusarium oxysporum f. sp. radicis-lycopersici treated with linalool
Tandem Mass Tag (TMT)-based quantitative proteomic analysis of tomato soil borne pathogen Fusarium oxysporum f. sp. radicis-lycopersici growth, and metabolism when treated with plant natural volatile organic compounds linalool. The Forl strain was cultured on PDA supplied with 0.8 mL/L linalool for ...
ORGANISM(S): Fusarium oxysporum f. sp. radicis-lycopersici 26381 
2023-03-11 | PXD038942 | Pride
Fusarium oxysporum Tmt Linalool Proteome 
UnknownMolecular Evolution of the Fusion (F) Genes in Human Parainfluenza Virus Type 2.
Not available
S-EPMC11857903 | biostudies-literature
UnknownHost Preference Associated With Deoxynivalenol and Nivalenol Chemotypes in Fusarium graminearum, F. asiaticum, and F. meridionale.
Not available
S-EPMC12904605 | biostudies-literature
UnknownDetailed Evolutionary Analyses of the F Gene in the Respiratory Syncytial Virus Subgroup A.
Not available
S-EPMC8706373 | biostudies-literature
UnknownAutomated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin.
Not available
S-EPMC8272768 | biostudies-literature
UnknownWheat Small GTPase Gene TaRABH1bL Is Involved in High-Temperature All-Stage Resistance to Puccinia striiformis f. sp. tritici.
Not available
S-EPMC12330980 | biostudies-literature
ProteomicsMutations to the ALS/FTD gene CCNF reveals elevated Lys48-linked ubiquitination by the SCF(cyclin F) complex
Approximately 10% of Amyotrophic lateral sclerosis (ALS) cases have a positive family history (familial ALS) and appear clinically indistinguishable from sporadic cases. ALS and frontotemporal dementia (FTD) are fatal neurodegenerative disorders that have common molecular and pathogenic characterist...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-01 | PXD002011 | Pride
Motor neurone disease Als Ccnf Ubiquitin 
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