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ProteomicsSerpina1e mediates the exercise-induced enhancement of hippocampal memory
Although exercise improves cognition, the specific molecules responsible for these beneficial effects remain unclear. Here, we propose that the myokine Serpina1e acts as a molecular mediator for these effects. Using an in vivo myokine-labeling mouse model, we confirmed that the Serpina1 family of pr...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD055604 | Pride
Exercise Hippocampus Cognitive enhancement Serpina1e Skeletal muscle Memory Neurogenesis Bdnf Myokine 
ProteomicsSuper-resolution proximity labeling method with enhanced direct identification of biotinylation sites
Promiscuous labeling enzymes, such as APEX2 or TurboID, are commonly used in in situ biotinylation studies of subcellular proteomes or protein-protein interactions. Although the conventional approach of enriching biotinylated proteins is widely implemented, in-depth identification of specific biotin...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047979 | Pride
Biotinylation site Apex2 Turboid Lc-ms Membrane protein topology Bioid Proximity labeling 
ProteomicsProximity labelling reveals intracristal quality control in mitochondria
The intracristal space (ICS) is a distinct subdomain of the mitochondrial intermembrane space (IMS) where oxidative phosphorylation occurs. This region supposedly controls the dynamic demands regulating mitochondrial respiration; however, its other molecular components remain largely unknown. To rem...
ORGANISM(S): Homo sapiens (Human) 
2025-07-02 | PXD039492 | Pride
Human Apex2 Mitochondria Cristae Proximity labelling 
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