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ProteomicsSerpina1e mediates the exercise-induced enhancement of hippocampal memory
Although exercise improves cognition, the specific molecules responsible for these beneficial effects remain unclear. Here, we propose that the myokine Serpina1e acts as a molecular mediator for these effects. Using an in vivo myokine-labeling mouse model, we confirmed that the Serpina1 family of pr...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD055604 | Pride
Exercise Hippocampus Cognitive enhancement Serpina1e Skeletal muscle Memory Neurogenesis Bdnf Myokine 
Unknownα-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling.
Not available
S-EPMC9067931 | biostudies-literature
UnknownBlockade of High-Fat Diet Proteomic Phenotypes Using Exercise as Prevention or Treatment.
Not available
S-EPMC7950115 | biostudies-literature
TranscriptomicsFormylpeptide Receptor Activation Attenuates Renovascular Remodeling in Neurogenic Hypertension (Kidney)
Inflammation and sympathetic overactivity contribute to end-organ injury associated with hypertension. We previously demonstrated that targeting formylpeptide receptors (FPRs), which regulate and resolve inflammation, prevents cardiovascular damage in preclinical hypertension. Here, we investigated ...
ORGANISM(S): Mus musculus 
2026-07-07 | GSE333587 | GEO
TranscriptomicsFormylpeptide Receptor Activation Attenuates Renovascular Remodeling in Neurogenic Hypertension (Left Ventricle)
Inflammation and sympathetic overactivity contribute to end-organ injury associated with hypertension. We previously demonstrated that targeting formylpeptide receptors (FPRs), which regulate and resolve inflammation, prevents cardiovascular damage in preclinical hypertension. Here, we investigated ...
ORGANISM(S): Mus musculus 
2026-07-07 | GSE333586 | GEO
ProteomicsBlockade of High-Fat Diet Phenotypes using Exercise as Prevention versus Treatment
The increasing consumption of high-fat western foods combined with a lack of exercise is a major contributor to the burden of obesity in humans. Aerobic exercise such as running is known to provide metabolic benefits, but how the over-consumption of a high fat diet (HFD) and exercise interact is not...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-02 | PXD018561 | Pride
Mouse Exercise Plasma High fat diet 
ProteomicsSystems Proteomics of the Intermittent Fasting Response Identifies a Key Role for HNF4a
Intermittent fasting (IF) increases lifespan, decreases metabolic disease phenotypes, and cancer risk in model organisms, but the mechanisms mediating these effects are not fully characterized. In particular, the altered transcriptional programming has yet to be defined in key fasting responsive tis...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-30 | PXD015553 | Pride
Mouse Intermittent fasting Proteomics Metabolomics Srebp1c Plasma Ppara Liver Hnf4a 
UnknownComparative Proteomic Analysis of Liver Tissues and Serum in db/db Mice.
Not available
S-EPMC9455973 | biostudies-literature
UnknownProteomic analysis revealed common, unique and systemic signatures in gender-dependent hepatocarcinogenesis.
Not available
S-EPMC7427087 | biostudies-literature
ProteomicsUntargeted proteomics profiling of liver and plasma in fed and fasted Glycogen Storage Disease type Ia (GSD Ia) mice: towards pathophysiological mechanisms and potential protein biomarkers for hepatic GSD Ia
Glycogen storage disease type Ia (GSD Ia) is a rare autosomal recessive disorder caused by a deficiency in glucose 6-phosphatase-α (G6PC). Patients primarily suffer from failure to thrive, hepatomegaly and severe fasting intolerance, biochemically characterized by hypoketotic and hyperlipidemia. Sin...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD054398 | Pride
Proteomics Plasma Liver Gsd ia Biomarkers 
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