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ProteomicsAnalysis of mng-SHIP1-dCT with pY Peptide by HDX-MS
Hydrogen deuterium exchange mass spectrometry (HDX-MS) was used to analyze how the mng-SHIP1-dCT construct interacts receptor-derived phosphotryrosine peptides (pY) to probe how these peptides regulate SHIP1 autoinhibition. This HDX-MS helped to identify intramolecular contacts involved in the regul...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD058704 | Pride
Ship1 Hdx-ms 
ProteomicsAnalysis of mini-SHIP1 with pY Peptide by HDX-MS
Hydrogen deuterium exchange mass spectrometry (HDX-MS) was used to analyze how the mini-SHIP1 construct interacts with receptor-derived phosphotryrosine peptides (pY) to probe how these peptides regulate SHIP1 autoinhibition. This HDX-MS helped to identify intramolecular contacts involved in the reg...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD061719 | Pride
Ship1 Hdx-ms 
TranscriptomicsTranscriptomic analysis of femoral diaphysis and primary osteoprogenitor cells cultures from mouse strains with SHIP1 deficiency and controls
Investigation of the SHIP1 (Inpp5d)-dependent and Rag2/Il2rg-dependent transcriptional changes in bone and osteoprogenitor cells cultures from murine strains with SHIP1 deficiency (Inpp5dm1Btlr/ m1Btlr, http://www.informatics.jax.org/allele/key/65037) and controls. Specifically, transcriptomic anal...
ORGANISM(S): Mus musculus 
2024-02-21 | E-MTAB-13164 | biostudies-arrayexpress
GenomicsSHIP1 is required for T cell surveillance of occult malignancies
SHIP1 is required for T cell surveillance of occult malignancies
PRJNA1378887 | ENA
GenomicsTranscriptomic analysis of femoral epiphysis from mouse strains with SHIP1 deficiency and controls
Transcriptomic analysis of femoral epiphysis from mouse strains with SHIP1 deficiency and controls
PRJEB79720 | ENA
ProteomicsMicroglial SHIP1 controls synaptic pruning in the developing hippocampus via the complement system
INPP5D, which encodes the lipid phosphatase SHIP1, is one of the most common genes associated with the risk of Alzheimer’s disease and is enriched in microglia in the central nervous system. SHIP1 has been found to be highly expressed in plaque-associated microglia. However, how it regulates microgl...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-04 | PXD052118 | Pride
Complement Ship1 Synaptic pruning Inpp5d Microglia 
TranscriptomicsSHIP1 is required for T cell surveillance of occult malignancies
SHIP1-deficient mice develop severe, transmural Crohn's-like ileitis and die prematurely. Recent analysis of a human Crohn's disease (CD) cohort revealed a significant subset of patients have severely reduced levels of SHIP1 expression suggesting SHIP1 deficiency leads to CD in both rodents and huma...
ORGANISM(S): Mus musculus 
2026-07-10 | GSE313296 | GEO
GenomicsMicroglial SHIP1 controls synaptic pruning in the developing hippocampus via the complement system
Microglial SHIP1 controls synaptic pruning in the developing hippocampus via the complement system
PRJNA1171307 | ENA
GenomicsMicroglial SHIP1 controls synaptic pruning in the developing hippocampus via the complement system
Microglial SHIP1 controls synaptic pruning in the developing hippocampus via the complement system
PRJNA1116096 | ENA
UnknownInterleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-inflammatory Effects through SHIP1/STAT3 Complexes.
Not available
S-EPMC7452241 | biostudies-literature
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