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TranscriptomicsMOTS-c: A Novel Peptide Encoded by a Short Mitochondrial Open Reading Frame Regulates Metabolic Homeostasis
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The recent identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of addi...
ORGANISM(S): Homo sapiens 
2015-03-07 | E-GEOD-65068 | biostudies-arrayexpress
GenomicsTranslation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation. Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively oncogenic non-canonical open reading frames. To address this question, we performed ribosome profiling of 32 medullob...
EGAS00001007426 | EGA
ProteomicsTMT-based quantitative proteomic analysis of SAHA-treated human HeLa cells
We performed a TMT-based quantitative proteomic analysis of SAHA-perturbed human HeLa cells using advanced RTS platform on Orbitrap Eclipse Tribrid MS system.
ORGANISM(S): Homo Sapiens (human) 
2023-06-09 | PXD038681 | JPOST Repository
TranscriptomicsK562 polyA RNA-Seq
RNA-Seq reads and TopHat (Trapnell et al. Bioinformatics 2009) alignments of K562 cell-line transcriptome. These were used to validate the expression of short peptides idenitified by Mass-Spectrometry in K562 cells. K562 polyA+ RNA (Batch 1) and total RNA (batch 2) was purchased from Ambion. We use...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-GEOD-34740 | biostudies-arrayexpress
TranscriptomicsHigh-resolution view of the yeast meiotic program revealed by ribosome profiling
Meiosis is a complex developmental process that generates haploid cells from diploid progenitors. We measured mRNA abundance and protein production through yeast sporulation and found strong temporal control for most genes, achieved through both mRNA levels and translational regulation. Monitoring t...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-06 | E-GEOD-34082 | biostudies-arrayexpress
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD036997 | Pride
Microproteins Small peptides Human Prm 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames Part1
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD033651 | Pride
Microproteins Proteomics Human Interactome 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames Part2
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD033629 | Pride
Microproteins Proteomics Human Interactome 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames Part3
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD033630 | Pride
Microproteins Proteomics Human Interactome 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames Part4
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD033631 | Pride
Microproteins Proteomics Human Interactome 
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