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TranscriptomicsModulation of gene expression in heart and liver of hibernating black bears (Ursus americanus)
We analyzed gene expression in the American black bear, Ursus americanus, using a custom 12,800 cDNA probe (BA02) microarray to detect differences in expression that occur in heart and liver during winter hibernation in comparison to summer active animals. We identified 245 genes in heart and 319 ge...
ORGANISM(S): Ursus americanus 
2011-05-10 | E-GEOD-27875 | biostudies-arrayexpress
TranscriptomicsCyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility.
Mitochondria control bioenergetics and cell fate decisions, but whether they also participate in extra-organelle signaling is not understood. Here, we show that interference with cyclophilin D (CypD), a mitochondrial matrix protein and apoptosis regulator, causes accelerated cell proliferation and ...
ORGANISM(S): Mus musculus 
2013-03-08 | E-GEOD-41280 | biostudies-arrayexpress
TranscriptomicsExamination of the MAPK pathway gene expression in patient samples
Microarray analysis of total RNA isolated from samples of circulating tumor cells from 7 patients before romidepsin infusion (0 hours), at 4 h after initiation of the infusion (4 hours) and 24 h after initiation of the infusion (24 hours). MAPK pathway related genes were selected to see differences ...
ORGANISM(S): Homo sapiens 
2013-06-03 | E-GEOD-45405 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles in Peripheral Blood Mononuclear Cells Can Distinguish Patients with NonSmall Cell Lung Cancer.
We report a 29-gene diagnostic signature, which distinguishes individuals with NSCLC from controls with non-malignant lung disease with 91% Sensitivity, 79% Specificity and a ROC AUC of 92%. Accuracy on an independent set of 18 NSCLC samples from the same location was 79%. Samples from an independe...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-13255 | biostudies-arrayexpress
TranscriptomicsThe Sp100 component of ND10/PML bodies is a potent tumor suppressor
The Sp100 component of ND10/PML bodies is a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program. Identifying the functions of proteins, which define specific subnuclear structures and territorie...
ORGANISM(S): Homo sapiens 
2012-12-04 | E-GEOD-20613 | biostudies-arrayexpress
UnknownHuman breast cancer associated fibroblasts exhibit subtype specific gene expression profiles
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-37614 | biostudies-other
TranscriptomicsHuman breast cancer associated fibroblasts exhibit subtype specific gene expression profiles
Breast cancer is a heterogeneous disease for which prognosis and treatment strategies are largely governed by the receptor status (estrogen, progesterone and Her2-neu) of the tumor cells. Gene expression profiling of whole breast tumors further stratifies breast cancer into several molecular subtyp...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-37614 | biostudies-arrayexpress
GenomicsAlternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development
Mammalian development is an intricate process regulated by multiple gene isoforms and their epigenetic states, which are yet undefined. Using integrative massive parallel sequencing and bioinformatics approach, we built genome-wide inventory of transcript variants, their promoters and histone modifi...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-23525 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of PBMC from HIV and HIV/TB co-infected patients
Diagnosis of TB, especially in the presence of an HIV co-infection, can be challenging when using conventional diagnostic methods. In this study, we analyzed global gene expression data from PBMC of patients that were either mono-infected with HIV or co-infected with HIV and TB in order to identify...
ORGANISM(S): Homo sapiens 
2014-03-05 | E-GEOD-50834 | biostudies-arrayexpress
TranscriptomicsDNA methylation analysis of PBMC from HIV and HIV/TB co-infected patients
Genome wide DNA methylation profiling of PBMC from South African patients either infected with HIV only or coinfected with HIV and tuberculosis (TB). The Illumina Infinium 27k Human DNA methylation Beadchip was used to obtain DNA methylation profiles from PBMC samples. Samples included 19 HIV patien...
ORGANISM(S): Homo sapiens 
2014-03-05 | E-GEOD-50835 | biostudies-arrayexpress
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