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ProteomicsYi-xin-shu Capsule Ameliorates Cardiac Hypertrophy by Regulating RB/HDAC1/GATA4 Signaling Pathway in Abdominal Aorta Coarctation-Induced Rat Model
Background: Cardiac hypertrophy (CH) is the main pathological basis of malignant cadiovascular diseases such as chronic heart failure (CHF). Mitigating and preventing CH is the key strategy for the treatment of ventricular remodeling in CHF. Yi-Xin-Shu capsule (YXS) is highly applied in clinical tre...
ORGANISM(S): Rattus Rattus 
2021-05-26 | PXD026267 |
UnknownStandardized Chinese Formula Xin-Ke-Shu inhibits the myocardium Ca(2+) overloading and metabolic alternations in isoproterenol-induced myocardial infarction rats.
Not available
S-EPMC4960537 | biostudies-literature
ProteomicsUncover New Reactivity of Genetically Encoded Alkyl Bromide Unnatural Amino Acids
Genetically encoded unnatural amino acids (Uaas) with electrophilic moieties are excellent tools to investigate protein-protein interactions (PPIs) both in vitro and in vivo. These Uaas, including a series of alkyl bromide-based Uaas, mainly target cysteine residues to form protein-protein cross-lin...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-04-04 | PXD031159 | Pride
Chemical cross-linking And sumo interactome Unnatural amino acid Protein-protein interactions Genetic code expansion 
ProteomicsFine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development
Abstract Spatiotemporal regulation of the mechanistic target of rapamycin (mTOR) pathway is pivotal for establishment of brain architecture. Dysregulation of mTOR signaling is associated with a variety of neurodevelopmental disorders (NDDs). Here, we discover that the UBE4B-KLHL22 E3 ubiquitin ligas...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-12 | PXD035852 | Pride
Mouse brain Ms Ube4b 
UnknownNovel practical stereoselective synthesis of a bicyclic hydantoino-thiolactone as the key intermediate for production of (+)-biotin†‡ † Dedicated to esteemed Professor Li-Xin Dai on the occasion of his 100th birthday.‡ Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3ra04721k
Not available
S-EPMC10475979 | biostudies-literature
MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
UnknownPostoperative Pain in Patients Undergoing Cancer Surgery and Intravenous Patient-Controlled Analgesia Use: The First and Second 24 h Experiences.
Not available
S-EPMC9845484 | biostudies-literature
UnknownSilencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-κB Through the Modulation of IκBα Sumoylation.
Not available
S-EPMC6972929 | biostudies-literature
UnknownSpongy titanosilicate promotes the catalytic performance and reusability of WO3 in oxidative cleavage of methyl oleate.
Not available
S-EPMC8981253 | biostudies-literature
UnknownPain Incidence and Associated Risk Factors among Cancer Patients within 72 Hours after Surgery: A Large Retrospective Analysis.
Not available
S-EPMC9858544 | biostudies-literature
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