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TranscriptomicsTranscriptional regulation of the sialic acid utilization gene cluster of Bifidobacterium breve UCC2003 by a GntR-type transcriptional repressor.
Members of the genus Bifidobacterium are typically found in the gastrointestinal tract (GIT) of humans and other mammals. Bifidobacterium breve strains are numerically prevalent among the gut microbiota of healthy, breast-fed infants. The metabolism of sialic acid, a ubiquitous monosaccharide in the...
ORGANISM(S): Bifidobacterium breve UCC2003 
2015-03-05 | E-GEOD-62885 | biostudies-arrayexpress
TranscriptomicsMetabolism of sialic acid by Bifidobacterium breve UCC2003
Bifidobacteria constitute a specific group of commensal bacteria which inhabit the gastrointestinal tract of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilise several plant-derived carbohydrates that include cellodextrins, starch and galactan. In the curren...
ORGANISM(S): Bifidobacterium breve UCC2003 
2014-05-29 | E-GEOD-56291 | biostudies-arrayexpress
ProteomicsA Linkage- Specific Sialic Acid Labeling Strategy Reveals Different Site-Specific Glycosylation Patterns in SARS-CoV-2 Spike Protein Produced in CHO and HEK Cell Substrates
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus utilizes an extensively glycosylated spike protein that protrudes from the viral envelope to bind to angiotensin-converting enzyme-related carboxypeptidase (ACE2) as its primary receptor to mediate host-cell entry. Currently, the...
ORGANISM(S): Homo sapiens (Human) Cricetulus barabensis 
2022-02-17 | PXD027536 | Pride
Lc-msms Glycopeptide Recombinant sars-2 spike Sialic acids labeling 
ProteomicsSialic acid-mediated mechanical activation of β2 adrenergic receptors by bacterial pili
Meningococcus utilizes β-arrestin selective activation of endothelial cell β2 adrenergic receptor (β2AR) to cause meningitis in humans. Molecular mechanisms of receptor activation by the pathogen and of its species selectivity remained elusive. We report that β2AR activation requires two asparagine-...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD015389 | Pride
Proline effect Human β-adrenergic receptor Pilin Q-exactive Blood-brain barrier Internal fragments N-glycan 
GenomicsMHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses
MHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses
PRJNA1101441 | ENA
TranscriptomicsMHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses
Influenza A viruses (IAV) cause seasonal outbreaks that pose a substantial burden on human health. They are also a zoonotic threat as avian and swine IAV can be a source for pandemic influenza. Receptor specificity is a critical determinant of tropism, host range and transmissibility of IAV and thus...
ORGANISM(S): Homo sapiens 
2024-06-17 | GSE264198 | GEO
TranscriptomicsSevere Preeclampsia-Related Changes in Gene Expression at the Maternal-Fetal Interface Include Siglec-6 and Pappalysin-2
Preeclampsia (PE), which affects 4-8% of human pregnancies, causes significant maternal and neonatal morbidity and mortality. Within the basal plate, placental cytotrophoblasts (CTBs) of fetal origin invade the uterus and extensively remodel the maternal vasculature. In PE, CTB invasion is often sha...
ORGANISM(S): Homo sapiens 
2009-02-06 | E-GEOD-14722 | biostudies-arrayexpress
GenomicsMitochondrial dysfunction enhances influenza pathogenesis by upregulating sialic acid biosynthesis
Mitochondrial dysfunction enhances influenza pathogenesis by upregulating sialic acid biosynthesis
PRJNA1181897 | ENA
UnknownTrisaccharide containing α2,3-linked sialic acid is a receptor for mumps virus.
Not available
S-EPMC5068328 | biostudies-literature
UnknownSialic Acid Receptors of Viruses.
Not available
S-EPMC7120183 | biostudies-literature
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