Sort   by:  
 Page size 
ProteomicsComprehensive redox profiling of the thiol proteome of Clostridium difficile
The strictly anaerobic bacterium C. difficile has become one of the most problematic hospital acquired pathogens and a major burden for health care systems. Although antibiotics work effectively in most C. difficile infections (CDIs), their detrimental effect on the intestinal microbiome paves the w...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2018-03-05 | PXD007278 | Pride
Thiol redox proteomics Clostridium difficile 
UnknownPooled-Analysis of Association of Sievers Bicuspid Aortic Valve Morphology With New Permanent Pacemaker and Conduction Abnormalities After Transcatheter Aortic Valve Replacement.
Not available
S-EPMC9178076 | biostudies-literature
TranscriptomicsMixture models and wavelet transforms reveal high confidence RNA-protein interaction sites in MOV10 PAR-CLIP data
The Photo-Activatable Ribonucleoside-enhanced CrossLinking and ImmunoPrecipitation (PAR-CLIP) method was recently developed for global identification of RNAs interacting with proteins. The strength of this versatile method results from induction of specific T to C transitions at sites of interaction...
ORGANISM(S): Homo sapiens 
2012-08-07 | E-GEOD-37524 | biostudies-arrayexpress
ProteomicsMyxopyronin B inhibits growth of a Fidaxomicin-resistant Clostridioides difficile isolate and interferes with toxin synthesis
Fidaxomicin is considered the current gold standard antibiotic for treating Clostridioides difficile infections and kills bacterial cells by inhibition of the RNA polymerase through binding to its switch region. Although binding sites do not overlap, also Myxopyronin B inhibits the RNA polymerase by...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2021-12-21 | PXD027366 | Pride
Clostridioides difficile Rna polymerase inhibitors Fidaxomicin Rifaximin Toxins Antibiotic resistance Antibiotic therapy Myxopyronin b 
ProteomicsThe proteomic response of Clostridioides difficile to the atypical tetracycline amidochelocardin and concomitant dissipation of its proton motive force
Amidochelocardin is an atypical tetracycline which was previously shown to target the bacterial cell membrane although its detailed mode-of-action is still unknown. To gain insight into Clostridioides difficile’s response to membrane targeting antibiotics and to further study the mode-of-action of A...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2022-08-04 | PXD029250 | Pride
Clostridioides difficile Amidochelocardin Tetracycline Antibiotic resistance Phenazine biosynthesis Antibiotic therapy Dissipation of the proton motive force 
TranscriptomicsExpression analysis of Listeria monocytogenes LO28 delta-lhrC1-5 mutant and LO28 wt
Investigation of whole genome gene expression level changes in Listeria monocytogenes LO28 delta-lhrC1-5 mutant, compared to the wild type strain. The lhrC1-5 genes encode the regulatory sRNAs LhrC1-5. The microarray studied the gene expression of unstressed cells and cells exposed to cefuroxime for...
ORGANISM(S): Listeria monocytogenes LO28 
2015-05-19 | E-GEOD-68996 | biostudies-arrayexpress
ProteomicsFlavodoxin Landscape in Clostridioides difficile
C. difficile infections have become a major challenge in medical facilities today. The bacterium is capable of spore formation, which even allows survival of antibiotic treatment. Therefore, research on the physiology of C. difficile is important for the development of alternative treatment strategi...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2024-02-02 | PXD041951 | Pride
Expression profiling Mass spectrometry Parallel reaction monitoring 
UnknownLamin A/C directs nucleosome-scale chromatin remodeling to define early lineage segregation in mammals.
Not available
S-EPMC12773000 | biostudies-literature
ProteomicsDifferences in gene expression between colony and aggregate biofilms of Clostridioides difficile revealed by proteomic profiling
The protein inventory of the anaerobic pathogen Clostridioides difficile grown in colony or aggregate biofilms was investigated in a comprehensive LC-MS/MS approach. C. difficile has a versatile metabolism and is perfectly equipped to survive and persist inside the mammalian intestine. However, know...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2021-07-12 | PXD022830 | Pride
Rpon signaling Clostridioides difficile Biofilm Persistence Cell surface antigens Lc-ms/ms 
TranscriptomicsRadicicol treatment of Drosophila cells
Drosophila S2 cells were treated with Heat-shock protein 90 (Hsp90) inhibitor radicicol for 15min, 30min and 1h. Poly(A) RNA was isolated and sequenced. Kinetics of transcriptional response to Hsp90 inhibition
ORGANISM(S): Drosophila melanogaster 
2012-05-14 | E-GEOD-35812 | biostudies-arrayexpress
Sort   by:  
 Page size