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ProteomicsStructural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b
Sialic acid-binding Ig-like lectin 15 (Siglec-15) is emerging as an immune modulator and target for cancer immunotherapy. However, limited knowledge regarding its mechanism of action and structure, or its binding partners with T cells, restrains the development of drug candidates that could unleash ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD042009 | Pride
Antibody Cancer Molecular recognition. X-ray crystallography Sialic acid Cd11b T cells Nmr Siglec-15 
GenomicsRNA sequencing to determine gene expression changes in Siglec-15 knockdown oteosarcoma cells
RNA sequencing to determine gene expression changes in Siglec-15 knockdown oteosarcoma cells
PRJNA732360 | ENA
GenomicsEffect of deficiency of Siglec-15 during osteoclast differentiation of murine bone marrow macrophages
Effect of deficiency of Siglec-15 during osteoclast differentiation of murine bone marrow macrophages
PRJNA905426 | ENA
TranscriptomicsRNA sequencing to determine gene expression changes in Siglec-15 knockdown oteosarcoma cells
In our study, we found that Siglec-15 was critical to osteosarcoma characteristics. To identify the downstream target genes of Siglec-15 in osteosarcoma, we conducted the RNA-seq analysis of Siglec-15 knockdown in osteosarcoma cell line 143B cells.
ORGANISM(S): Homo sapiens 
2021-05-25 | GSE175414 | GEO
TranscriptomicsEffect of deficiency of Siglec-15 during osteoclast differentiation of murine bone marrow macrophages
To investigate the function of Siglec-15 in the regulation of osteoclast differentiation, Siglec-15 deficient mice was established. Then gene expression profiling analysis using data obtained from RNA-seq of bone marrow macrophages with M-CSF and RANKL at two different time points was performed.
ORGANISM(S): Mus musculus 
2023-12-01 | GSE218768 | GEO
UnknownDevelopment of an immunohistochemical assay for Siglec-15.
Not available
S-EPMC9253057 | biostudies-literature
UnknownHigh affinity monoclonal antibody targeting Siglec-15 for cancer immunotherapy.
Not available
S-EPMC8710358 | biostudies-literature
GenomicsTumor-derived kynurenine induces Siglec-15 expression and promotes CD8+T cell exhaustion in oral squamous cell carcinoma
Tumor-derived kynurenine induces Siglec-15 expression and promotes CD8+T cell exhaustion in oral squamous cell carcinoma
PRJNA923002 | ENA
UnknownSiglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases.
Not available
S-EPMC6941304 | biostudies-literature
UnknownAnalysis of a novel immune checkpoint, Siglec-15, in pancreatic ductal adenocarcinoma.
Not available
S-EPMC8977273 | biostudies-literature
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