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ProteomicsSialoglycans Modulate Siglec-5 – TLR4 Interactions in Osteoarthritis
Osteoarthritis (OA) is characterized by chronic, low-grade inflammation that contributes to cartilage degradation and joint pain. We previously identified Siglec-5/14 in synovial fluid of OA patients (OA SF), which prompted us to investigate its interaction with the sialylated proinflammatory recept...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD069055 | Pride
Tlr4 : osteoarthritis Siglec-5 Siglec-14 Sialic acid Monocytes 
TranscriptomicsGene expression profiles of Siglec-14/THP-1 and Siglec-5/THP cell lines, with or without NTHi stimulation
Acquisition of a new strain of non-typeable Haemophilus influenzae (NTHi) is often associated with exacerbation of chronic obstructive pulmonary disease (COPD). We have previously reported that COPD patients who are homozygous null for SIGLEC14 gene is less susceptible to COPD exacerbation than thos...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-47929 | biostudies-arrayexpress
UnknownImmunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.
Not available
S-EPMC4682649 | biostudies-literature
UnknownSialoglycans modulate Siglec-5-TLR4 interactions in osteoarthritis.
Not available
S-EPMC12677102 | biostudies-literature
UnknownStructural implications of Siglec-5-mediated sialoglycan recognition.
Not available
S-EPMC2245879 | biostudies-literature
UnknownSiglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.
Not available
S-EPMC4042635 | biostudies-literature
UnknownMolecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV).
Not available
S-EPMC5656783 | biostudies-literature
UnknownNeisserial adhesin A (NadA) binds human Siglec-5 and Siglec-14 with high affinity and promotes bacterial adhesion/invasion.
Not available
S-EPMC11323535 | biostudies-literature
UnknownSoluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity.
Not available
S-EPMC5125011 | biostudies-literature
TranscriptomicsGene expression profiles of Siglec-14/THP-1 and Siglec-5/THP cell lines, with or without NTHi stimulation
Acquisition of a new strain of non-typeable Haemophilus influenzae (NTHi) is often associated with exacerbation of chronic obstructive pulmonary disease (COPD). We have previously reported that COPD patients who are homozygous null for SIGLEC14 gene is less susceptible to COPD exacerbation than thos...
ORGANISM(S): Homo sapiens 
2014-08-04 | GSE47929 | GEO
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