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ProteomicsThe Inhibitory Receptor Siglec-8 Interacts with FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation
Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory diseases where MCs have a central role in pathogenesis. Targeting Siglec-8, an inhibitory receptor on MCs and eosinophils, has shown promising activity in preclinical and clinical studies. While the intracellular p...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-21 | PXD030820 | Pride
Siglec-8 Mast cell 
ProteomicsSiglec-3 (CD33) and Siglec-8 ligands
Identification of human brain ligand for the microglial inhibitory receptors Siglec-3 (CD33) and Siglec-8
ORGANISM(S): Homo Sapiens (human) 
2022-03-07 | PXD032064 | JPOST Repository
UnknownSiglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties.
Not available
S-EPMC5458540 | biostudies-literature
UnknownExpression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells.
Not available
S-EPMC4355580 | biostudies-literature
UnknownDiscovery, Function, and Therapeutic Targeting of Siglec-8.
Not available
S-EPMC7823959 | biostudies-literature
UnknownOptimizing Siglec-8-Directed Immunotherapy for Eosinophilic and Mast Cell Disorders.
Not available
S-EPMC11506601 | biostudies-literature
UnknownFrontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls.
Not available
S-EPMC7585130 | biostudies-literature
UnknownSialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways.
Not available
S-EPMC6142871 | biostudies-literature
UnknownSialylated keratan sulfates on MUC5B are Siglec-8 ligands in the human esophagus.
Not available
S-EPMC11364441 | biostudies-literature
UnknownA Sulfonamide Sialoside Analogue for Targeting Siglec-8 and -F on Immune Cells.
Not available
S-EPMC6861165 | biostudies-literature
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