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TranscriptomicsA novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa
Next to the two-component and quorum sensing systems, cell-surface signaling (CSS) has been recently identified as an important regulatory system in Pseudomonas aeruginosa. CSS senses signals from outside the cell and transmits them into the cytoplasm. It consists of a TonB-dependent outer membrane ...
ORGANISM(S): Pseudomonas aeruginosa 
2009-04-21 | E-GEOD-15697 | biostudies-arrayexpress
TranscriptomicsSigma factor E of Mycobacterium tuberculosis controls the expression of bacterial components that modulate macrophages
Sigma factor E (SigE) controls the expression of genes that are essential for Mtb virulence. In this work, we have identified the SigE regulon during infection of macrophages Our results indicate that SigE regulates the expression of genes involved in the maintenance of Mtb cell envelope integrity a...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-7962 | biostudies-arrayexpress
TranscriptomicsGenome-scale reconstruction of the sigma factor network in E. coli
We report the application of single-molecule-based sequencing technology for high-throughput profiling of transcription start sites for Escherichia coli under different conditions. By obtaining sequence from 5' RACE (rapid amplification of cDNA ends) followed by deep sequencing, we generated genome-...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2014-02-05 | E-GEOD-46737 | biostudies-arrayexpress
TranscriptomicsRole of the extracytoplasmic-function sigma Factor sigmaH in Mycobacterium tuberculosis global gene expression
Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (s) factors encoded in its genome. In previously published work, we and others have shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and, in ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-03 | E-GEOD-8689 | biostudies-arrayexpress
TranscriptomicsSigma factor B (sigB) response to stress conditions (0.05% SDS and 5mM Diamide)
The numerous sigma factors present in Mycobacterium tuberculosis (MTB) are indicative of adaptability to different environmental conditions. In this report we describe the sigma factor B (sigB) regulon and the phenotypes of a MTB sigB mutant strain exposed to different stresses like SDS and Diamide....
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-25 | E-GEOD-15976 | biostudies-arrayexpress
TranscriptomicsAnalysis of sigma factor-dependent gene expression in Pseudomonas aeruginosa by RNA sequencing
Sigma factors are master regulators of bacterial transcription which direct gene expression of specific subsets of genes. In particular, alternative sigma factors are well-known to be key players of bacterial adaptation to changing environments. To elucidate the regulatory network of sigma factors i...
ORGANISM(S): Pseudomonas aeruginosa 
2015-02-12 | E-GEOD-54998 | biostudies-arrayexpress
MetabolomicsSequential lipidomic, metabolomic, and proteomic analyses of serum, liver, and heart tissue specimens from peroxisomal biogenesis factor 11α knockout mice
Peroxisomes are versatile single membrane-enclosed cytoplasmic organelles, involved in reactive oxygen species (ROS) and lipid metabolism and diverse other metabolic processes. Peroxisomal disorders result from mutations in Pex genes-encoded proteins named peroxins (PEX proteins) and single peroxiso...
2022-02-02 | MTBLS1887 | MetaboLights
ProteomicsEscherichia coli S2P family intramembrane protease RseP is engaged in the regulated sequential cleavages of FecR in the ferric citrate signaling
Escherichia coli RseP, a member of the S2P family intramembrane proteases, is involved in the activation of the σE extracytoplasmic stress response and the elimination of remnant signal peptides. It remains however unclear whether RseP has additional cellular functions. In this study, we attempted t...
ORGANISM(S): Escherichia Coli 
2021-04-14 | PXD023797 | JPOST Repository
TranscriptomicsIdentification of the alternative sigma factor SigX regulon and its implications for Pseudomonas aeruginosa pathogenicity
We analyzed a deletion mutant of the ECF M-OM-^C factor SigX and applied mRNA profiling to define the SigX dependent regulon in P. aeruginosa in response to low osmolarity medium conditions. Furthermore, the combination of transcriptional data with chromatin immunoprecipitation (ChIP) followed by hi...
ORGANISM(S): Pseudomonas aeruginosa UCBPP-PA14 
2013-11-11 | E-GEOD-50937 | biostudies-arrayexpress
ProteomicsLysine acetylation of the housekeeping sigma factor enhances the activity of RNA polymerase holoenzyme
Protein lysine acetylation is one of the abundant post-translational modifications in eukaryotes, but found in prokaryotes as well. Despite the evidence of the lysine acetylation in the prokaryotic RNA polymerases (RNAPs), its function remains unrevealed. We revealed that the housekeeping sigma fact...
ORGANISM(S): Streptomyces venezuelae 
2020-05-27 | PXD015174 | Pride
Sigma factor Lysine acetylation Rna polymerase Transcription 
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