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TranscriptomicsCyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility.
Mitochondria control bioenergetics and cell fate decisions, but whether they also participate in extra-organelle signaling is not understood. Here, we show that interference with cyclophilin D (CypD), a mitochondrial matrix protein and apoptosis regulator, causes accelerated cell proliferation and ...
ORGANISM(S): Mus musculus 
2013-03-08 | E-GEOD-41280 | biostudies-arrayexpress
TranscriptomicsGene expression arrays of cardiomyocyte ribosome-associated RNAs during zebrafish heart regeneration
A transgenic line cmlc2:TRAP was made to express EGFP-fused ribosomal protein L10a (EGFP-L10a) in zebrafish cardiomyocytes. Then ribosome-associated RNAs were immuoprecipitated from uninjured and injured adult cmlc2:TRAP fish to determine the differential expression changes during zebrafish heart re...
ORGANISM(S): Danio rerio 
2013-08-01 | E-GEOD-48914 | biostudies-arrayexpress
Metabolomics1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty
Neutrophil function declines with age, but little is known about the changes in neutrophil metabolism that take place in robust older people and older people with frailty. We used 1H-NMR spectroscopy to investigate the metabolomic and lipidomic profiles of blood neutrophils from healthy y...
2026-03-26 | MTBLS6055 | MetaboLights
TranscriptomicsExpression and Splicing Analysis of Myotonic Dystrophy and Other Dystrophic Muscle
The prevailing patho-mechanistic paradigm for myotonic dystrophy (DM) is that the aberrant presence of embryonic isoforms is responsible for many, if not most, aspects of the pleiotropic disease phenotype. In order to identify such aberrantly expressed isoforms in skeletal muscle of DM type 1 (DM1)...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-48828 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of end-stage renal disease patients and healthy controls
Genome-wide methylation profiling performed on whole blood DNA samples from three groups: 1 - Dialysis patients at baseline (before treatment) and after 12 months of dialysis (n=12) 2 - Renal transplant patients at baseline (before treatment) and after 12 months of dialysis (n=12) 3 - Healthy contro...
ORGANISM(S): Homo sapiens 
2017-08-01 | E-MTAB-4931 | biostudies-arrayexpress
UnknownThe Doubled-Edged Sword of T1-Mapping in Systemic Sclerosis-A Comparison with Infectious Myocarditis Using Cardiovascular Magnetic Resonance.
Not available
S-EPMC7278005 | biostudies-literature
ProteomicsProteomic analysis of healthy and hyperglycemic murine fetal kidneys
Alteration of kidney morphogenesis in diabetic pregnancies is poorly described, especially changes in the extracellular matrix (ECM) and glomerular basement membrane (GBM during glomerulogenesis. Addressing the ECM proteome, or matrisome, in the mouse fetal kidney in a healthy and diabetic environme...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-13 | PXD025874 | Pride
Mass spectrometry Basement membrane Enrichment Kidney Extracellular matrix Diabetes 
TranscriptomicsGlobal changes in gene expression in dermal fibroblasts with in vivo and in vitro deletion of the RBP-Jk gene
It is currently unclear whether tissue changes surrounding multifocal epithelial tumors are a cause or consequence of cancer. Here, we provide evidence that loss of mesenchymal Notch/CSL signaling causes tissue alterations, including stromal atrophy and inflammation, which precede and are potent tri...
ORGANISM(S): Mus musculus 
2012-06-11 | E-GEOD-36359 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of Arabidopsis thaliana esr1-1 mutant versus wild-type (JC66)
A GSTF8 promoter fragment fused to the luciferase reporter gene was used in a forward genetic screen for Arabidopsis mutants with up-regulated GSTF8 promoter activity and identified the esr1-1 (enhanced stress response 1) mutant which also conferred increased resistance to the fungal pathogen Fusari...
ORGANISM(S): Arabidopsis thaliana 
2015-04-25 | E-MTAB-4235 | biostudies-arrayexpress
TranscriptomicsGene expression profile of TGFβ3 stimulation and TRPV4 activation/inhibition in the TC28a2 human chondrocyte cell line
RNA-seq of TC28a2 cells following TRPV4 activation/inhibition in the presence and absence of prior TGFβ3 stimulation. The experiment was performed to determine the effect of TRPV4 activity on gene expression in the presence and absence of TGFβ stimulation. TGFβ3 was used to stimulate TGFβ signalling...
ORGANISM(S): Homo sapiens 
2022-01-17 | E-MTAB-10279 | biostudies-arrayexpress
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