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MetabolomicsTetrandrine regulates NAADP-mediated calcium signalling 1 through a novel LIMP-2-dependent, sphingosine-mediated mechanism.
Tetrandrine (Tet) is an highly potent inhibitor of Ebola virus replication by blocking NAADP51 dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent. Using a clickable, photoaffinity probe of Tet, we identified lysosomal integral membrane p...
2025-05-23 | MTBLS12492 | MetaboLights
MetabolomicsMulti-omics and biophysical phosphoproteomics uncover functional phosphorylation networks of BRAFV600E-driven signaling

Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
MetabolomicsDefective cytokinin signaling reprograms lipid and flavonoid gene-to-metabolite networks to mitigate high salinity in Arabidopsis

Cytokinin (CK) in plants regulates both developmental processes and adaptation to environmental stress. Arabidopsis histidine phosphotransfer ahp2,3,5 and type-B response regulator arr1,10,12 triple mutants are almost completely defective in CK signaling, and the ahp2,3,5

2021-11-25 | MTBLS2532 | MetaboLights
TranscriptomicsAnalyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models
Understanding the structure and interplay of cellular signalling pathways is one of the great challenges in molecular biology. Boolean Networks can infer signalling networks from observations of protein activation. In situations where it is difficult to assess protein activation directly, Nested Eff...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-68761 | biostudies-arrayexpress
GenomicsActivin/Nodal signalling controls divergent transcriptional networks in pluripotent and endoderm progenitors.
Activin/Nodal signalling is necessary to maintain pluripotency of human Embryonic Stem Cells (hESCs) and to induce their differentiation towards endoderm. However, the mechanisms by which Activin/Nodal signalling achieves these opposite functions remain unclear. To unravel these mechanisms, we exami...
ORGANISM(S): Homo sapiens 
2011-11-11 | E-GEOD-19461 | biostudies-arrayexpress
MetabolomicsCommon mycelial network modulates neighbour-primed plant defences against foliar pathogens by co-opting distinct inter-plant metabolic and biotic stress responses
This study contains raw and processed mass spectrometry-based metabolomics data from Medicago truncatula plants used to investigate inter-plant signalling through arbuscular mycorrhizal fungal common mycelial networks. The experiment examined metabolomic responses in receiver plants following stress...
2026-06-30 | MTBLS14821 | MetaboLights
UnknownConstitutively active NDR1-PIF kinase functions independent of MST1 and hMOB1 signalling.
Not available
S-EPMC4049220 | biostudies-literature
ProteomicsProteomic mapping of the interactome of KRAS mutants identifies new features of RAS signalling networks and the mechanism of action of Sotorasib.
RAS proteins are key regulators of cell signalling and are master regulators of different cell functions including cell proliferation, differentiation and cell death. Point mutations in the genes of this family are common, particularly in the KRAS. These mutations were thought to cause the constativ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-15 | PXD043536 | Pride
Apms Ras Signalling 
ProteomicsCommunity detection from empirical kinase networks identifies new members of signalling pathways
We use phosphorylation sites to quantify the enrichment of kinase-kinase relationships in response to diferent kinase inhibitors, from which we construct weighted kinase networks, and assess whether the application of community detection algorithms to such networks can provide new insights on the in...
ORGANISM(S): Homo sapiens (Human) 
2023-06-07 | PXD026039 | Pride
Phosphoproteomics Kinase networks Bioinformatics Communitiy detection 
TranscriptomicsOptogenetic manipulation of BMP signalling to drive chondrogenic differentiation of hPSCs
Optogenetics is a rapidly advancing technology that combines photochemical, optical and synthetic biology techniques to control cellular behaviour and physiology. Combining sensitive light responsive optogenetic intervention tools with human pluripotent stem cell differentiation models has the poten...
ORGANISM(S): Homo sapiens 
2023-11-09 | E-MTAB-13377 | biostudies-arrayexpress
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