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ProteomicsStructural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
The antibiotic resistance protein FusB rescues protein synthesis from inhibition by fusidic acid (FA), which locks elongation factor G (EF-G) to the ribosome after GTP hydrolysis. Here, we present time-resolved single-particle cryo-EM structures explaining the mechanism of FusB-mediated rescue. FusB...
ORGANISM(S): Staphylococcus aureus 
2025-05-07 | PXD062129 | Pride
Cryo-em Elongation factor g Ribosome Fusidic acid Fusb 
ProteomicsA Macrophage-Collagen Fragment Axis Mediates Subcutaneous Adipose Tissue Remodeling
Efficient collagen degradation is essential for adaptive subcutaneous adipose tissue (SAT) expansion that protects against ectopic lipid deposition during weight gain. Here, we aimed to further define the mechanism for this collagenolytic process. We show that loss of collagen type-1 (CT1) and incre...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD043721 | Pride
Collagen fragments Macrophages Fibrosis Ecm-remodeling Collagen endocytosis Subcutaneous adipose tissue Cd206 
ProteomicsAssociation of progesterone levels with pain intensity and synoviocyte activation in postmenopausal female subjects with knee osteoarthritis
Objective. Post-menopausal female subjects are overrepresented among people with knee osteoarthritis (OA) and report worse pain compared to male subjects of similar age and radiographic score. Our study investigated whether plasma levels of gonadal hormones are associated with pain intensity, radiog...
ORGANISM(S): Homo sapiens (Human) 
2026-10-07 | PXD061120 | Pride
Synovial tissue Knee osteoarthritis Quantitative proteomics Plasma progesterone 
ProteomicsEvaluation of Acute and Subacute Toxicity of Plant Cell Cultures of Scurvy Grass (Cochlearia danica) and Rowan (Sorbus aucuparia) as Food by Oral Administration in Mice
Plant cell culture (PCC) technology is currently being developed to produce plant foods partially decoupled from traditional agriculture practices. By now, the safety of the ingredients produced by PCC technology for food or nutritional purposes has to be tested. Therefore, the objective of this stu...
ORGANISM(S): Cochlearia danica Sorbus aucuparia 
2025-11-10 | PXD065550 | Pride
Plant cell cultures  acute toxicity  subacute toxicity  safety  cochlearia danica  sorbus aucuparia 
ProteomicsStaphylococcus aureus mutants resistant to the feed-additive monensin show increased virulence and altered purine metabolism
Ionophores are antibacterial compounds that affect bacterial growth by changing intracellular concentrations of the essential cations, sodium and potassium. They are extensively used in animal husbandry to increase productivity and reduce infectious diseases. Given their widespread usage, it is impo...
ORGANISM(S): Staphylococcus aureus 
2024-01-09 | PXD047199 | Pride
Virulence Monensin Purine metabolism S. aureus Ionophore resistance 
ProteomicsComparative analysis of commercial human primary mesangial cell, implications for experimental design.
Research on human glomerular mesangial cells (MCs) is mainly performed in vitro on primary MCs. Commercially available MCs originate from different donors and thus, because of their origin, the outcome of the experiments could potentially be affected. We have compared two commercially available pr...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD060148 | Pride
Pdgf-bb primary human mesangial cells mesangium glomerulus Quantitative proteomics 
ProteomicsNovel insights on remnant stomach following Roux-en-Y Gastric Bypass surgery based on histological evaluation and quantitative proteomics analysis
Background: Patients undergoing weight-reducing Roux-en-Y gastric bypass (RYGB) have immediate positive effects on metabolic health, including type 2 diabetes (T2D). Refeeding via the secluded stomach, either by a gastrotube or after gastro-gastric fistulation result in T2D relapse and weight regain...
ORGANISM(S): Homo sapiens (Human) 
2025-07-17 | PXD065508 | Pride
Human  proteomic remnant stomach  roux-en-y gastric bypass 
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