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MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
MetabolomicsIntegrating Blood Microsampling Devices with CE-MS for Untargeted Analysis of Polar Metabolomics

Capillary electrophoresis–mass spectrometry (CE-MS) offers considerable advantages for polar compound metabolomics analysis, including simple workflows, fast method development, and suitability for small sample volumes. Blood microsampling (BμS) techniques (such as dried blood spots, quantitative...

2026-01-13 | MTBLS13090 | MetaboLights
MetabolomicsRhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells (LC-MS)

Circadian clocks coordinate mammalian behaviour and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), which do not contain a nucleus, and cannot perfor...

2020-11-13 | MTBLS1285 | MetaboLights
MetabolomicsRhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells (GC-MS)

Circadian clocks coordinate mammalian behaviour and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), which do not contain a nucleus, and cannot perfor...

2020-11-13 | MTBLS1286 | MetaboLights
MetabolomicsComprehensive lipid analysis of green Arabica coffee beans by LC-HRMS/MS
Lipids play an important role in coffee bean development, coffee brew and in the effects of coffee on human health. They account for around 17% of the dry bean weight and encompass different classes and subclasses, mostly triacylglycerols (TAG) and a minor quantity of phospholipids (PL) and βN-alkan...
2021-11-19 | MTBLS1972 | MetaboLights
MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
TranscriptomicsThe Role of Interleukin-11 in the Development of the Autoimmune Response in Multiple Sclerosis
Our results introduce interleukin (IL)-11 as a new cytokine that may play a role in the development of the autoimmune response in patients with relapsing remitting multiple sclerosis (RR MS). IL-11 was found to be the highest up-regulated cytokine in the serum and cerebrospinal fluid (CSF) from pat...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-59085 | biostudies-arrayexpress
TranscriptomicsMethanol effect on an E. coli BW25113 strain expressing heterologous mdh and das enzymes during or after growth on xylose
In this project we used the strain E. coli BW25113 ΔfrmA::frt (Δ(araD-araB)567, ΔlacZ4787(::rrnB-3), λ-, rph-1, Δ(rhaD-rhaB)568, hsdR514, ΔfrmA(::frt)) from the Keio collection (Baba et al. 2006). The plasmid {pSEVA424_mdh-das} (Low-copy-number, lacIq/Ptrc promoter, RK2 ori, SmR) from Silva-Rocha et...
ORGANISM(S): Escherichia coli K-12 
2020-07-10 | E-MTAB-8909 | biostudies-arrayexpress
ProteomicsE2 Rad6 controls cellular response to oxidative stress
Protein ubiquitination is an essential process that rapidly regulates protein synthesis, function, and fate in dynamic environments. Among its non-proteolytic functions, K63 ubiquitin accumulates in yeast cells exposed to oxidative stress, stalling ribosomes at elongation. K63 ubiquitin conjugates a...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-12 | PXD025727 | Pride
Yeast Rad6 Oxidative stress Ubiquitin Translation 
Transcriptomicsaffy_ath_2012_04-Functional characterization of JMJ24, a putative histone demethylase
affy_ath_2012_04 - affy_ath_2012_04 - Epigenetic informations include histone post-translational modifications such as acetylation and methylation. The jumoni proteins can remove the methyl group from lysine or arginine residues of histones. The aim of this project is to compare gene expression leve...
ORGANISM(S): Arabidopsis thaliana 
2013-08-01 | E-GEOD-43728 | biostudies-arrayexpress
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