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MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
MetabolomicsEpithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice an...
2018-08-13 | MTBLS523 | MetaboLights
MetabolomicsLimitations to Starch Utilization in Barramundi (Lates calcarifer) as Revealed by NMR-Based Metabolomics
Practical diets for commercial barramundi production rarely contain greater than 10% starch, used mainly as a binding agent during extrusion. Alternative ingredients such as digestible starch have shown some capacity to spare dietary protein catabolism to generate glucose. In the present study, a ca...
2020-07-30 | MTBLS1103 | MetaboLights
ProteomicsA novel TTBK2 missense variant causes loss of function and impaired protein phosphorylation: implications for spinocerebellar ataxia type 11
Spinocerebellar ataxia type 11 (SCA11) is a rare form of autosomal dominant cerebellar ataxia, characterized by a relatively slow progression and normal life expectancy. However, it is a highly debilitating disorder. In 2007, SCA11 was genetically linked to TTBK2, which encodes tau tubulin kinase 2 ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD056662 | Pride
Spinocerebellar ataxia type 11 (sca11)  tau-tubulin kinase 2 (ttbk2)  crispr/cas9  kinase activity  phosphoproteomics  cytoskeleton 
MetabolomicsMetabolic effects of dietary glycerol supplementation in muscle and liver of European seabass and rainbow trout by 1H NMR metabolomics
The sustainable growth of fish aquaculture will require the procurement of non-marine feed sources. Glycerol is a potential feed supplement whose metabolism may spare the catabolism of dietary amino acids, thereby extending the use of the feed protein to other physiological functions such as growth....
2020-02-24 | MTBLS832 | MetaboLights
ProteomicsMare endometritis and endometrial fibrosis
Mare persistent post-breeding endometritis may lead to endometrosis, characterized by excessive fibrosis, which is a major cause of subfertility/infertility. The aim of this work was to compare the proteome of equine endometrium from categories IIA and IIB, with and without endometritis, to identify...
ORGANISM(S): Equus caballus (Horse) 
2026-09-28 | PXD070769 | Pride
Mare Endometrial proteome Endometrial fibrosis Endometritis 
MetabolomicsRhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells (LC-MS)

Circadian clocks coordinate mammalian behaviour and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), which do not contain a nucleus, and cannot perfor...

2020-11-13 | MTBLS1285 | MetaboLights
UnknownEffectiveness of HPV vaccination in reducing infection among young Brazilian women.
Not available
S-EPMC11749143 | biostudies-literature
ProteomicsMudPIT analyses of whole cell extracts from Y1 murine adrenocortical carcinoma cell line stimulated with serum or FGF2
Fibroblast growth factor 2 (FGF2) is well known as a promoter of cell proliferation, however, in some cellular contexts, it can induce cell cycle arrest or cell death. In Y1 murine adrenocortical carcinoma cell line, FGF2 induces G0/G1 transition but delays S-phase progression and permanently block ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-10-23 | MSV000081638 | MassIVE
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