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ProteomicsIntracellular and extracellular proteome characterization of virulent and avirulent Bursaphelenchus xylophilus isolates
The pinewood nematode (PWN), Bursaphelenchus xylophilu (Bx) s, one of the most serious forest pests, worldwide, is considered the causal agent of the pine wilt disease (PWD). The main host species belong to the genus Pinus and a variation in the susceptibility of several pine species to PWN infectio...
ORGANISM(S): Bursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides xylophilus) cellular organisms 
2022-01-13 | PXD029377 | Pride
Proteomics Intracellular proteome  extracellular proteome  bursaphelenchus xylophilus Avirulent isolate Virulent isolate Pinewood nematode 
TranscriptomicsRNA-seq of whole blood samples from patients with visceral leishmaniasis.
To ascertain which molecular pathways underlying the pathogenesis of human visceral leishmaniasis (VL) caused by the protozoan parasite Leishmania infantum, we performed modular co-expression gene networks analysis using CEMiTool R package and the transcriptional profile of whole blood samples from ...
ORGANISM(S): Homo sapiens 
2018-01-25 | E-MTAB-6137 | biostudies-arrayexpress
ProteomicsNew insights on sperm function in male infertility of unknown origin: proteomics characterization
The global trend on (male)infertility is concerning and the unidentifiable causes in half of the cases demands a better understanding of the molecular, biochemical and metabolic mechanisms as well as the identification of external and internal factors operating behind it, that might help to explain ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-28 | PXD040292 | Pride
Xxxxxxidiopathic male infertility  unexplained male infertility  sperm function  sperm proteomics 
ProteomicsAnother layer of complexity in Staphylococcus aureus methionine biosynthesis control: Unusual RNase III-driven T-box riboswitch cleavage determines met operon mRNA stability and decay
In Staphylococcus aureus, de novo methionine biosynthesis is regulated by a unique hierarchical pathway involving stringent-response controlled CodY repression in combination with a T-box riboswitch and RNA decay. The T-box riboswitch residing in the 5' untranslated region (met leader RNA) of the S....
ORGANISM(S): Staphylococcus aureus (strain Newman) 
2021-08-10 | PXD020619 | Pride
Methionine biosynthesis Staphylococcus aureus Rna decay T-box riboswitch 
TranscriptomicsTrancriptome analysis of peripheral leukocytes from SARS-CoV-2 infected patients and healthy uninfected individuals during the first wave of COVID-19 pandemic in Brazil
To evaluate the gene expression profiling of peripheral leukocytes in different outcomes of SARS-CoV-2 infections, whole blood samples were collected from individuals with positive SARS-CoV-2 nasopharyngeal swab by RT-PCR (54 patients) and healthy uninfected individuals (12 volunteers). Infected pat...
ORGANISM(S): Homo sapiens 
2022-04-29 | E-MTAB-11240 | biostudies-arrayexpress
TranscriptomicsBulk mRNA-seq of blood samples of visceral leishmaniasis patients during active disease and after treatment (cured), asymptomatic individuals and healthy uninfected control volunteers.
To ascertain which genes are involved in the outcome of Leishmania infantum infections and immunopathology of human visceral leishmaniasis (VL), we investigated the transcriptional profile of whole blood samples from patients during active VL compared to the same patients 180 days after being treate...
ORGANISM(S): Homo sapiens 
2022-03-10 | E-MTAB-11047 | biostudies-arrayexpress
ProteomicsAnother layer of complexity in Staphylococcus aureus methionine biosynthesis control: Unusual RNase III-driven T-box riboswitch cleavage determines met operon mRNA stability and decay
In Staphylococcus aureus, de novo methionine biosynthesis is regulated by a unique hierarchical pathway involving stringent-response controlled CodY repression in combination with a T-box riboswitch and RNA decay. The T-box riboswitch residing in the 5' untranslated region (met leader RNA) of the S....
ORGANISM(S): Staphylococcus aureus (strain Newman) 
2021-02-18 | PXD022677 | Pride
Methionine biosynthesis Staphylococcus aureus Rna decay T-box riboswitch 
TranscriptomicsRNA-seq of blood samples from patients diagnosed with visceral leishmaniasis and asymptomatic individuals (Brazil)
To ascertain which genes are involved in the outcome of Leishmania infantum infection and immunopathology of human visceral leishmaniasis (VL), we investigated the transcriptional profile of whole blood samples from patients diagnosed with active VL compared to asymptomatic individuals (positive ser...
ORGANISM(S): Homo sapiens 
2020-08-06 | E-MTAB-8818 | biostudies-arrayexpress
UnknownAntiviral activity of ouabain against a Brazilian Zika virus strain.
Not available
S-EPMC9308787 | biostudies-literature
ProteomicsBursaphelenchus xylophilus secretome under Pinus pinaster and P. pinea stimuli
The pinewood nematode, Bursaphelenchus xylophilus, the pine wilt disease's causal agent, is a migratory endoparasitic nematode skilled to feed on pine tissues and on fungi that colonize the trees. In order to study B. xylophilus secretomes under the stimulus of pine species with different susceptibi...
ORGANISM(S): Bursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides xylophilus) 
2021-04-27 | PXD024011 | Pride
Pinus pinaster Swath-ms Bursaphelenchus xylophilus P. pinea Secretome 
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