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TranscriptomicsTranscription profiling of Drosophila body wall and wing/hinge fragments from wing imaginal discs to identify genes with localized expression patterns
Wing imaginal discs were dissected to generate body wall and wing/hinge fragments. Targets from three biological replicates of each were generated and the expression profiles were determined using Affymetrix Drosophila Genechip 1 arrays. Comparisons between the sample groups allow the identificati...
ORGANISM(S): Drosophila melanogaster 
2007-07-06 | E-GEOD-93 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis to identify Egfr-responsive genes
The highly conserved Epidermal Growth Factor-receptor (Egfr) pathway is required in all animals for normal development and homeostasis; consequently, aberrant Egfr signaling is implicated in a number of diseases. Genetic analysis of Drosophila melanogaster Egfr has contributed significantly to under...
ORGANISM(S): Drosophila melanogaster 
2012-01-06 | E-GEOD-34872 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila cell lines: RasV12, four samples of CL8 and one sample of L2 reveal expression of oncogenic ras allows efficient generation of continuous cell lines
Analysis of cells in culture has made substantial contributions to biological research. The versatility and scale of in vitro manipulation and new applications such as high throughput gene silencing screens ensure the continued importance of cell-culture studies. In comparison to mammalian systems, ...
ORGANISM(S): Drosophila melanogaster 
2008-04-05 | E-GEOD-10781 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila cell lines overexpressing Ras
RasV12 was used to drive the generation of cell lines from primary cultures. Lines have been passaged for over a year, indicating that they are true lines. Experiment Overall Design: RasV12 drove the creation of cell lines from primary culture. The array datasets were created from passage 11 cells...
ORGANISM(S): Drosophila melanogaster 
2008-06-16 | E-GEOD-9366 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of whole transcriptome in E(z) temperature sensitive cells [RNA-Seq]
PcG protein complex PRC2 is a methyltransferase specific for histone H3 lysine27, and H3K27me3 is essential for stable transcription silencing. Less well known but quantitatively much more important is the genome-wide role of PRC2 that dimethylates ~70% of total H3K27. Here we show that H3K27me2 occ...
ORGANISM(S): Drosophila melanogaster 
2015-05-14 | E-GEOD-61307 | biostudies-arrayexpress
GenomicsGenome-wide analysis of histone marks in E(z) temperature sensitive cells [ChIP-seq]
PcG protein complex PRC2 is a methyltransferase specific for histone H3 lysine27, and H3K27me3 is essential for stable transcription silencing. Less well known but quantitatively much more important is the genome-wide role of PRC2 that dimethylates ~70% of total H3K27. Here we show that H3K27me2 occ...
ORGANISM(S): Drosophila melanogaster 
2015-05-14 | E-GEOD-64219 | biostudies-arrayexpress
GenomicsGenome-wide analysis of epigenetic marks in E(z) temperature sensitive cells [ChIP-seq]
PcG protein complex PRC2 is a methyltransferase specific for histone H3 lysine27, and H3K27me3 is essential for stable transcription silencing. Less well known but quantitatively much more important is the genome-wide role of PRC2 that dimethylates ~70% of total H3K27. Here we show that H3K27me2 occ...
ORGANISM(S): Drosophila melanogaster 
2015-05-14 | E-GEOD-61308 | biostudies-arrayexpress
TranscriptomicsDistribution of H3K27me3, H3K27ac, and H3K4me1 in E(z) temperature sensitive cells
PcG protein complex PRC2 is a methyltransferase specific for histone H3 lysine27, and H3K27me3 is essential for stable transcription silencing. Here we have determined genomic distributions of H3K27me3, H3K27ac, and H3K4me1 in cultured Drosophila E(z) temperature sensitive cells at 25°C and 31°C whe...
ORGANISM(S): Drosophila melanogaster 
2015-05-14 | E-GEOD-61262 | biostudies-arrayexpress
TranscriptomicsDiscovery of progenitor signatures by time series synexpression analysis during Drosophila cell immortalization [Microarray Expression]
To characterize the sequence of events associated with RasV12 immortalization of Drosophila embryonic cells, we generated transcriptional time series during cell line establishment, from primary cultures until passage (P) 19. We generated two transcriptional time series from two cell lines (R3 and R...
ORGANISM(S): Drosophila melanogaster 
2015-09-23 | E-GEOD-73335 | biostudies-arrayexpress
TranscriptomicsDiscovery of progenitor signatures by time series synexpression analysis during Drosophila cell immortalization [RNA-Seq]
To characterize the sequence of events associated with RasV12 immortalization of Drosophila embryonic cells, we generated transcriptional time series during cell line establishment, from primary cultures until passage (P) 19. We generated three transcriptional time series from three cell lines (R1, ...
ORGANISM(S): Drosophila melanogaster 
2015-09-24 | E-GEOD-73353 | biostudies-arrayexpress
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