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OtherInflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.
Data from ProteomeXchange, PXD ID: PXD001500. Experiment: IFNAR_KO_Prog_78a, file: 120503_JH_IFNAR_KO_Prog_78a_10.mzml. Published as part of Cell Stem Cell. 2015 Aug 19. pii: S1934-5909(15)00306-9 . From the Abstract: {{i}} ... Here, we report that the phenotypic hematopoietic stem cell (HSC) compa...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310023393 | GPMDB
Resource Reanalysis 
ProteomicsSILAC-iPOND analysis of WT vs ATRX KO eHAP cells ± HU
Mutations in the ATRX chromatin remodeller predispose to a developmental genetic disorder and cancer, but how ATRX safeguards genome and telomere stability remains unresolved. Here, we uncover critical dependencies for the CTC1-STN1-TEN1 (CST) complex and RAD9A-HUS1-RAD1 (9-1-1) clamp in ATRX defici...
ORGANISM(S): Homo sapiens (Human) 
2026-05-19 | PXD068487 | Pride
UnknownGeneration of precision preclinical cancer models using regulated in vivo base editing.
Not available
S-EPMC11295146 | biostudies-literature
UnknownBase editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Not available
S-EPMC9232935 | biostudies-literature
UnknownOptimized base editors enable efficient editing in cells, organoids and mice.
Not available
S-EPMC6130889 | biostudies-literature
TranscriptomicsA histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.
Wildtype and set2delta strains, with samples taken at t=0 and following 30 minutes treatment with 5 µg/ml bleomycin.
ORGANISM(S): Schizosaccharomyces pombe 
2014-06-09 | E-MTAB-2549 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 10 sample types: normal colon tissue, non cancerous adenomas, Dukes B carcinomas, Dukes C carcinomas, Dukes D carcinomas, and liver metastases, see also E-TIGR-14, E-TIGR-15
This study was designed to find patterns of gene expression in colon cancer samples that correlate with clinical stage. Ten samples were profiled from each of the following sample types: normal colon tissue, noncancerous adenomas, Dukes B carcinomas, Dukes C carcinomas, Dukes D carcinomas, and liver...
ORGANISM(S): Homo sapiens 
2005-01-01 | E-TIGR-14 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 17 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome
We have carried out microarray-based comparative genomic hybridisation (arrayCGH) on 17 Favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome. Tumour DNA was co-hybridised with normal female genomic D...
ORGANISM(S): Homo sapiens 
2006-05-11 | E-TABM-13 | biostudies-arrayexpress
TranscriptomicsGene expression profile of calcified and normal tricuspid aortic valves by RNA sequencing.
Purpose: Calcific aortic valve stenosis (AS) is a fatal disease with currently no medical therapy. Some genes were associated with AS, but the genetic architecture of the disease has yet to be discovered. The objective of this study was to combine genome-wide association studies (GWAS) and gene expr...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-55492 | biostudies-arrayexpress
TranscriptomicsA Myc transcriptional program that is independent of EMT drives a poor prognosis tumor-propagating phenotype in HER2+ breast cancer
The HER2 (ERBB2) and MYC genes are commonly amplified genes in breast cancer, yet little is known about their molecular and clinical interaction. Using a novel chimeric mammary transgenic approach and in vitro models, we demonstrate markedly increased self renewal and tumour propagating capability o...
ORGANISM(S): Homo sapiens 
2013-09-24 | E-GEOD-43730 | biostudies-arrayexpress
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