Sort   by:  
 Page size 
ProteomicsAxonal and somatodendritic proteomes of dopamine neurons in the mouse brain
Dopamine (DA) neurons modulate neural circuits and behaviors via dopamine release from expansive, long range axonal projections. The elaborate cytoarchitecture of DA neurons is embedded within complex brain tissues, making it difficult to access the DA neuronal proteome using conventional methods. H...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-01 | PXD026229 | Pride
Proteomics Apex2 Dopamine neurons Axon 
TranscriptomicsCell type-specific ribosome profiling in vivo.
We report cell-type specific ribosome profiling in a mouse glioma model. We report a strategy for cell-type specific ribosome profiling in vivo. Our strategy was applied to the characterization of a mouse glioma model.
ORGANISM(S): Mus musculus 
2014-08-25 | E-GEOD-51424 | biostudies-arrayexpress
TranscriptomicsDigital RNA Sequencing Minimizes Sequence-Dependent Bias and Amplification Noise with Optimized Single Molecule Barcodes
RNA-Seq is a powerful tool for transcriptome profiling, but is hampered by sequence-dependent bias and inaccuracy at low copy numbers intrinsic to exponential PCR amplification. We developed a simple strategy for mitigating these complications, allowing truly digital RNA-Seq. Following reverse tra...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2012-01-07 | E-GEOD-34449 | biostudies-arrayexpress
TranscriptomicsMRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma
We obtained radiographically-localized biopsies during glioma resection surgeries to sample the tumor core and margins from multiple glioma patients. We also procured fresh, non-neoplastic brain tissue specimens from multiple patients having procedures to relieve epilespy symptoms or to place shunts...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-59612 | biostudies-arrayexpress
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
TranscriptomicsGlobal gene expression response to BET inhibition in two cancer cell lines
The MYC transcription factor is a master regulator of diverse cancer pathways and somatic cell reprogramming. MYC is a compelling therapeutic target that exhibits cancer-specific cellular effects. Pharmacologic inhibition of MYC function has proven challenging due to its numerous modes of forced exp...
ORGANISM(S): Homo sapiens 
2011-09-18 | E-GEOD-29449 | biostudies-arrayexpress
TranscriptomicsSingle cell 5’ transcript, TCRαβ enriched, and Cell hashing/CITE-seq library preparation on the 10x chromium, and sequencing
Single cells from human colorectal cancer and normal adjacent colon of 16 patients were used for single-cell RNA-seq, TCR-seq, CITE-seq and Cell hashing. In brief, single cells were incubated for 3h with or without PMA/Ionomycin, and were treated with Cell hashing and CITE-seq antibodies to distingu...
ORGANISM(S): Homo sapiens 
2022-03-02 | E-MTAB-9455 | biostudies-arrayexpress
GenomicsAlzheimer's Disease Sequencing Project (ADSP)

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

phs000572.v1.p1 | EGA
UnknownGenetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Not available
S-EPMC6463297 | biostudies-literature
GenomicsATD
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
EGAD00000000011 | EGA
Sort   by:  
 Page size