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TranscriptomicsA genomic regulatory element that directs assembly and function of immunespecific AP-1-IRF complexes
This SuperSeries is composed of the following subset Series: GSE40726: Transcriptional profiling of IRF4 -/- vs IRF4 +/- T-cells under Th17 polarizing conditions GSE40727: ChIPseq analysis of IRF4 and BATF in immune cells Refer to individual Series
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-40483 | biostudies-arrayexpress
TranscriptomicsThe non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway
Acute myeloid leukemia is a heterogeneous disease with regard to the underlying genetic and molecular pathophysiology. Non-steroidal anti-inflammatory drugs (NSAIDs) exert significant anti-proliferative effects in various malignant cells in vitro and in vivo. Hence, these agents can be utilized to s...
ORGANISM(S): Homo sapiens 
2011-03-26 | E-GEOD-28185 | biostudies-arrayexpress
ProteomicsThe composition and structure of the outer kinetochore KMN complex is conserved across Kingdoms
In eukaryotes, chromosome segregation during cell division requires attachment to the spindle, which is ensured by a large multi-protein structure called the kinetochore. The outer layer of the kinetochore attaches to the microtubules and is named after three of its components KNL1C, MIS12C, and NDC...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-11-17 | PXD062209 | Pride
Ap-ms Arabidopsis Kinetochore Kmn complex 
TranscriptomicsA gene expression signature associated with K-Ras addiction reveals regulators of EMT and tumor cell survival
K-Ras mutations occur frequently in epithelial cancers. Using shRNAs to deplete K-Ras in lung and pancreatic cancer cell lines harboring K-Ras mutations, two classes were identified—lines that do or do not require K-Ras to maintain viability. Comparing these two classes of cancer cells revealed a g...
ORGANISM(S): Homo sapiens 
2009-03-06 | E-GEOD-15126 | biostudies-arrayexpress
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
TranscriptomicsCell cycle positioning drives heterogeneity within the pluripotent stem cell compartment
Heterogeneity in pluripotent cells marks a metastable state where cells may drift between native and lineage-primed populations. While the role for these heterogeneities are unclear, they may reflect the dynamic equilibriums of signaling networks and have a direct effect on differentiation potentia...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-53481 | biostudies-arrayexpress
ProteomicsMYB-regulated pancreatic cancer secretome
Earlier we have shown important roles of MYB in pancreatic tumor pathobiology. To better understand the role of MYB in the tumor microenvironment and identify MYB-associated secreted biomarker proteins, we conducted mass spectrometry analysis of the secretome from MYB-modulated and control pancreati...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015126 | Pride
Pancreatic cancer Myb Biomarkers Secretome 
TranscriptomicsGene expression of metabolically adaptable triple-negative breast cancer cells
To gain insight into the characteristic of metabolically adaptable MA cells that enables them to survive severe metabolic challenge, i.e., prolonged lack of glutamine and other challenges [Singh et al., PLoS ONE 7: e36510, 2012], we used gene expression microarrays to compare these cells with the pa...
ORGANISM(S): Homo sapiens 
2014-10-03 | E-GEOD-60016 | biostudies-arrayexpress
UnknownDoes acute pancreatitis herald pancreatic ductal adenocarcinoma? A multicenter electronic health research network study.
Not available
S-EPMC9939170 | biostudies-literature
UnknownTargeting Aberrant Expression of STAT3 and AP-1 Oncogenic Transcription Factors and HPV Oncoproteins in Cervical Cancer by Berberis aquifolium.
Not available
S-EPMC8580881 | biostudies-literature
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