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TranscriptomicsSingle nucleus RNA sequencing of human deep neck BAT
single-nucleus RNA sequencing is applied on human brown adipose tissue at deep neck.
ORGANISM(S): Homo sapiens 
2020-07-13 | E-MTAB-8564 | biostudies-arrayexpress
TranscriptomicsSingle nucleus RNA sequencing in mouse brown adipose tissue at room temperature, cold condition and thermoneutrality
Single nucleus RNA sequencing in mouse brown adipose tissue at room temperature, cold condition and thermoneutrality.
ORGANISM(S): Mus musculus 
2020-07-13 | E-MTAB-8562 | biostudies-arrayexpress
TranscriptomicsTrained and untrained human skeletal muscle single-nucleus RNA-sequencing from individuals with type 2 diabetes and control
Single-nuclei RNA sequencing (snRNA-seq) data of human muscle cells. The samples are a part of a study investigating the effect of one-legged high-intensity interval training (HIIT) on the nuclear transcriptional response in skeletal muscle. The HIIT was done on one leg on a cycle ergometer, and vas...
ORGANISM(S): Homo sapiens 
2025-04-24 | E-MTAB-15009 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus mRNA-sequencing reveals dynamics of lipogenic and thermogenic adipocyte populations in murine brown adipose tissue in response to cold exposure
Brown adipocyte-specific ChREBP knockout were generated by crossing mice with a floxed exon1a in the Mlxipl gene with Ucp1-Cre mice. These ChREBPflox/flox Ucp1-Cre+ (Cre+) mice and ChREBP-expressing control (Cre-) mice were studied under various conditions of BAT activation. Housing at room temperat...
ORGANISM(S): Mus musculus 
2025-11-10 | E-MTAB-15819 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus RNA-seq2 of liver tissue of 3 months old mice to investigate crosstalk between ploidy and zonation
Single-nucleus RNA-seq-2 method that allows deep characterization of nuclei isolated from frozen archived tissues. We have used this approach to characterize the transcriptional profile of individual hepatocytes with different levels of ploidy. This method has the potential to explore archived sampl...
ORGANISM(S): Mus musculus 
2021-05-06 | E-MTAB-9333 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus RNA sequencing of positional airway organoids derived from human fetal lung at 4 anatomic regions (trachea, bronchus, NCA, distal)
We derived primary, epithelial-enriched organoids from 120 PCD human fetal lung, specifically from trachea, bronchus, non-cartilaginous airway, and distal airway. These positional airway organoids were grown in FANY airway media for the duration of 2 passages before collection for single-nucleus RNA...
ORGANISM(S): Homo sapiens 
2025-08-01 | E-MTAB-14961 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus RNA-seq of liver tissue of 3 months old mice to investigate crosstalk between ploidy and zonation
Single-nucleus RNA-seq-2 method that allows deep characterization of nuclei isolated from frozen archived tissues. We have used this approach to characterize the transcriptional profile of individual hepatocytes with different levels of ploidy. This method has the potential to explore archived sampl...
ORGANISM(S): Mus musculus 
2021-05-06 | E-MTAB-10223 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus RNA-seq (10x Genomics Flex) of wild-type C57BL/6J mouse spleen following Plasmodium berghei ANKA infection, generated as a transcriptome-wide reference for the SpatialBench spatial transcriptomics benchmark
This dataset provides single-nucleus RNA-sequencing (snRNA-seq) profiles of wild-type mouse spleen, generated as a matched, transcriptome-wide reference for the SpatialBench resource benchmarking high-resolution spatial transcriptomics platforms (Visium HD, Xenium and MERSCOPE). Spleens were collect...
ORGANISM(S): Mus musculus 
2026-07-07 | E-MTAB-17245 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. Using single nucleus RNA-sequencing (snRNAseq) of isolated nuclei from muscle fibers, we investigated nuclear heterogeneity and transcriptional dynamics in uninjured and regenerating muscle.
ORGANISM(S): Mus musculus 
2020-10-07 | E-MTAB-8623 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus RNA-seq of adult chimpanzee and bonobo livers
Single-nucleus RNA-seq was performed on the liver samples from adult chimpanzees and bonobos. Two individuals were included for both species. The single-nucleus libraries were generated using the 10X Chromium Next GEM Single Cell 3ʹ platform and sequenced on Illumina NextSeq 550. This dataset is par...
ORGANISM(S): Pan paniscus 
2026-07-13 | E-MTAB-15548 | biostudies-arrayexpress
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