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MetabolomicsCardiac untargeted lipidomics in cardiomyocyte-specific SREBP1 knockdown mice

Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider...

2026-02-20 | MTBLS13696 | MetaboLights
TranscriptomicsA Global Genomic View of MIF Knockdown Cell
siRNA-mediated knockdown of MIF expression in HEK293 cells resulted in inhibition of cell proliferation and cell cycle progress. The microarray study of MIF KD cells reveald knockdown of MIF would lead to extensive changes in gene expression profiles which may elucidate the molecular mechanism of...
ORGANISM(S): Homo sapiens 
2009-11-02 | E-GEOD-10241 | biostudies-arrayexpress
TranscriptomicsGene profile in H1299 cells treated with PTD-DRBD GAPDH siRNA or treated with Lipofection GAPDH siRNA
Whole genome microarrays were probed with total mRNA from PTD-DRBD GAPDH siRNA treated H1299 cells at 12 h and 24 h. Using a 1.6x fold increase/decrease filter of cellular mRNAs, we detected a dramatic reduction in the target GAPDH mRNA along with a limited number of both up and down regulated genes...
ORGANISM(S): Homo sapiens 
2010-05-08 | E-GEOD-15723 | biostudies-arrayexpress
ProteomicsmARC1 knockdown protects liver from diet-induced NASH in mouse
Human genetic studies have identified several MARC1 variants as protective against non-alcoholic fatty liver diseases (NAFLD). The MARC1 variants are associated with reduced lipid profiles, liver enzymes, and liver-related mortality. However, the role of mitochondrial amidoxime reducing component 1 ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-28 | MSV000091820 | MassIVE
TranscriptomicsExpression profiling of human medulloblastoma cell line ONS76 upon siRNA-mediated knockdown of KDM5A/LSD1
KDM5A/LSD1 is an important epigenetic regulator in medulloblastoma, the most frequent brain tumor of childhood. Here, the response of ONS76 medulloblastoma cells upon siRNA-mediated knockdown of KDM5A is analysed. The expression profile of ONS76 cells upon KDM5A knockdown was compared to mock contro...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-43552 | biostudies-arrayexpress
GenomicssiRNA-mediated knockdown
siRNA-mediated knockdown
PRJNA541912 | ENA
TranscriptomicsAnalysis of global gene expression profiles of A549 cells treated with SETX siRNA upon Influenza A/PR/8/34(ΔNS1) Infection
Untransfected (no siRNA), control siRNA or SETX siRNA treated A549 cells were infected with A/Puerto Rico/8/1934(ΔNS1) for 4 hours 3 Biological Replicates per condition
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-52932 | biostudies-arrayexpress
GenomicsNuclear RNA-seq of siRNA-mediated METTL3 knockdown
Nuclear RNA-seq of siRNA-mediated METTL3 knockdown
PRJNA541844 | ENA
TranscriptomicsRNA sequencing (RNA-SEQ) of EPAS1 knockdown by siRNA in endothelial cells
Purpose: By integrating DNA methylation and gene expression of COPD lung tissues, we identified EPAS1 as a key regulator whose downstream genes significantly overlapped with multiple genes sets associated with COPD disease severity. EPAS1 is distinct in comparison with other key regulators in terms ...
ORGANISM(S): Homo sapiens 
2015-01-16 | E-GEOD-62974 | biostudies-arrayexpress
UnknownsiRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids.
Not available
S-EPMC3090230 | biostudies-literature
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