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MetabolomicsEndothelial Sirtuin1 Suppresses Whole-body Insulin Sensitivity by Modulating the Secretome
Not available
ORGANISM(S): Mus musculus 
ST002204 | MetabolomicsWorkbench
MetabolomicsThe effect of fasting and sirtuin overexpression on serum metabolome.
Not available
ORGANISM(S): Mus musculus 
ST001523 | MetabolomicsWorkbench
TranscriptomicsHistone/Protein Deacetylase-6, -9, and Sirtuin-1 Control Foxp3+ Treg Through Shared and Isotype-Specific Mechanisms
Targeting histone/protein deacetylase (HDAC)-6, -9, or Sirtuin-1 (Sirt1) augments the suppressive functions of Foxp3+ T regulatory (Treg) cells, but it is unclear if this involves different mechanisms, such that combined inhibition would be beneficial. We compared the suppressive functions of Tregs ...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36095 | biostudies-arrayexpress
ProteomicsSCFCyclin F targets the metabolic protein Sirtuin 5 for ubiquitination
Cell cycle transitions are regulated by a number of coordinating signaling events. The ubiquitin-proteasome system is an important part of this cell cycle signaling. Cyclin F, a substrate adapter for the SCF (SKP1/CUL1/F-box) E3 ubiquitin ligase, is an important regulator of cell cycle progression. ...
ORGANISM(S): Homo Sapiens (human) 
2020-11-17 | PXD019396 | JPOST Repository
ProteomicsSirtuin 5 Reduces Malonylation in Non-mitochondrial Metabolic Pathways in Diabetic Kidney Disease
Early diabetic kidney disease (DKD) is marked by dramatic metabolic reprogramming due to nutrient excess, mitochondrial dysfunction, and increased renal energy requirements from hyperfiltration. We hypothesized that changes in metabolism in DKD may be regulated by Sirtuin 5 (SIRT5), a deacylase that...
ORGANISM(S): Mus Musculus 
PXD037819 | panorama
ProteomicsAP-MS analysis of sirtuin-4 interactions in human fibroblasts
Sirtuins (SIRTs) form a critical family of nicotinamide adenine dinucleotide (NAD)-dependent enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, SIRTs4-7 have little to no deacetylase activity, and a robust catalytic activity for mitochondrial SIRT4 h...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-04 | MSV000079557 | MassIVE
TranscriptomicsNegative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging (microarray expression)
Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important rol...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-54436 | biostudies-arrayexpress
ProteomicsAccurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome
We applied SD-SILAC to determine absolute acetylation stoichiometry in exponentially-growing and stationary-phase wild type and sirtuin deacetylase CobB-deficient E. coli. We further assayed stoichiometry in phophotransacetylase (pta) and acetate kinase (ackA) mutant strains in the presence and abse...
ORGANISM(S): Escherichia coli 
2017-03-07 | PXD005757 | Pride
E. coli Sirtuin Acetylation Stoichiometry Cobb 
TranscriptomicsRNA-seq of human fibroblast cell cultures treated with resveratrol against DMSO treated controls, with and without siRNA treatment targeting SIRT1
Resveratrol (RSV) is a small compound with many reported beneficial effects, including increased expression of genes involved in inborn errors of metabolism. We wanted to investigate the effects of RSV on gene regulation on a global scale in order to detect new target genes for RSV mediated up-regul...
ORGANISM(S): Homo sapiens 
2018-11-12 | E-MTAB-7360 | biostudies-arrayexpress
ProteomicsIntegrated lysine acetylation stoichiometry and proteomics analysis in human cells
Lysine acetylation is a widespread posttranslational modification that targets a large number of biological pathways. Recent studies reveal that lysine acetylation sites exhibit mainly low stoichiometry. Here we explored three sample preparation methods, the use of detergents for the chemical acetyl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-09 | MSV000081704 | MassIVE
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