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UnknownAberrant femoral nerve anatomy: No longer a cause of block failure when using ultrasound guidance.
Not available
S-EPMC6299761 | biostudies-literature
UnknownCommunicating the risks of tobacco and alcohol co-use.
Not available
S-EPMC9708929 | biostudies-literature
UnknownN-terminal acetylation and arginylation of actin determines the architecture and assembly rate of linear and branched actin networks.
Not available
S-EPMC9597890 | biostudies-literature
UnknownUnusual Hypermucoviscous Clinical Isolate of Klebsiella pneumoniae with No Known Determinants of Hypermucoviscosity.
Not available
S-EPMC9241604 | biostudies-literature
ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067130 | Pride
Limk Protac 
ProteomicsA general workflow for E3 ligase ligand validation for PROTAC development
PROteolysis TArgeting Chimeras (PROTACs) have gained considerable attention as a new modality in drug discovery. However, the development of PROTACs has been mainly focused on CRBN (Cereblon) and VHL (van Hippel-Lindau Ligase) ligands. The considerable size of the human E3 ligase family, newly devel...
ORGANISM(S): Homo sapiens (Human) 
2025-04-04 | PXD057431 | Pride
Protac Vhl Promiscious kinase inhibitor 
UnknownmNG-tagged fusion proteins and nanobodies to visualize tropomyosins in yeast and mammalian cells.
Not available
S-EPMC9592052 | biostudies-literature
UnknownRapid production of pure recombinant actin isoforms in Pichia pastoris.
Not available
S-EPMC5976186 | biostudies-literature
ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067272 | Pride
Limk Protac 
ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067224 | Pride
Limk Protac 
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