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TranscriptomicsSumoylation-deficient bone marrow derived dendritic cells transcriptomic analysis after LPS stimulation
Bone marrow derived dendritic cells were generated from Ubc9[fl;-] and Ubc9[+/+] mice. After in vitro derivation in the presence of GM-CSF, dendritic cells were treated with tamoxifen for four days to cause CreERT2 activation, and induce Ubc9 floxed allele deletion. This allowed comparative transcri...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-66178 | biostudies-arrayexpress
TranscriptomicsGenome-wide inter-primate comparison of gene expression profiles in multiple tissues
Regulatory changes have long been hypothesized to play an important role in primate evolution. To identify adaptive regulatory changes in humans, we performed a genome-wide survey for genes whose regulation evolves under natural selection. To do so, we used a novel multi-species microarray to measur...
ORGANISM(S): Macaca mulatta 
2008-09-17 | E-GEOD-11560 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of PBMCs from type 1 diabetes patients treated with low-dose human interleukin-2
Type 1 diabetes patients received a daily subcutaneous injection of placebo or 0.33, 1 or 3 Millions IU of interleukin-2 (IL-2) for 5 consecutive days. Transcriptomic analysis was performed on PBMCs collected from patients before and after the IL-2 course.
ORGANISM(S): Homo sapiens 
2015-06-30 | E-MTAB-2858 | biostudies-arrayexpress
ProteomicsStoichiometry of the gene products from the tetrachloroethene reductive dehalogenase operon pceABCT
Organohalide respiration (OHR) is a bacterial anaerobic process in which halogenated compounds, e.g. tetrachloroethene (PCE), are used as terminal electron acceptors. Our model organisms are Dehalobacter restrictus strain PER-K23, an obligate OHR bacterium, and Desulfitobacterium hafniense strain TC...
ORGANISM(S): Dehalobacter restrictus Bacteria 
2022-04-06 | PXD030941 | Pride
Desulfitobacterium hafniense Firmicutes Organohalide respiration Tetrachloroethene Stoichiometry Reductive dehalogenase Quantitative proteomics Dehalobacter restrictus 
TranscriptomicsEarly dendritic cell molecular signature modelling predicts late vaccine-induced adaptive T-cell responses (Illumina)
Mice were vaccinated with different Lentivirus vector-plaforms or PBS. Transcriptomes of sorted dendritic cells 6 hours after vaccination were used to build a model predictive of the vector-platform efficacy measured as the antigen-specific response 5, 7 and 10 days after the vaccination Groups of 7...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-66797 | biostudies-arrayexpress
TranscriptomicsRestoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation
Systemic lupus erythematosus (SLE) is a T and B cell-dependent autoimmune disease characterized by the appearance of autoantibodies, a global regulatory T cells (Tregs) depletion and an increase in Th17 cells. Recent studies have shown the multifaceted immunomodulatory effects of vitamin D, notably ...
ORGANISM(S): Homo sapiens 
2012-03-29 | E-GEOD-36941 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [RVPC3_DAC]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53465 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_DAC]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53466 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53469 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_IFN]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53467 | biostudies-arrayexpress
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