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ProteomicsA Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription
Cells typically regulate their size within a relatively tight range by coupling growth to the cell division cycle using a dedicated set of molecular mechanisms. In budding yeast, cells are born with a similar amount of the G1/S inhibitor protein Whi5 that is then diluted by growth throughout G1. As ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-03-31 | PXD075635 | Pride
Whi5 Cell size Size scaling 
ProteomicsCell size-dependent mRNA transcription drives proteome remodeling
Increasing cell size drives proteomic changes that impact cell physiology. However, the molecular basis of size-dependent proteome remodeling has remained unclear. Here, we develop an inducible Cyclin D1 expression system in human cells to generate populations of proliferating cells spanning over a ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-03 | PXD076071 | Pride
Transcription Protein turnover Cell size Size scaling 
GenomicsDifferential scaling of gene expression with cell size may explain size control in budding yeast.
Differential scaling of gene expression with cell size may explain size control in budding yeast.
PRJNA606307 | ENA
GenomicsTranscriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size
Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size
PRJNA705222 | ENA
TranscriptomicsScaling of gene expression with liver cell size in vivo
A partially hepatectomized mouse liver with a liver-specific conditional Cdk1 knock-out genotype grows back to the normal size in the absence of cell divisions resulting in highly enlarged nuclear and cell size. This experiment analyses gene expression in four sets of mouse livers all with different...
ORGANISM(S): Mus musculus 
2014-03-06 | E-MTAB-1297 | biostudies-arrayexpress
GenomicsScaling of gene expression with liver cell size in vivo
Scaling of gene expression with liver cell size in vivo
PRJEB3304 | ENA
TranscriptomicsTranscriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size
Biosynthesis scales with cell size such that protein concentrations generally remain constant as cells grow. As an exception, synthesis of the cell-cycle inhibitor Whi5 ‘sub-scales’ with cell size so that its concentration is lower in larger cells to promote cell-cycle entry. Here, we find that a tr...
ORGANISM(S): Saccharomyces cerevisiae Schizosaccharomyces pombe 
2021-12-01 | GSE167842 | GEO
ProteomicsNeuronal proteome dynamics during homeostatic scaling.
Homeostatic scaling adjusts synaptic strength in response to persistent changes in neuronal network activity. This compensatory mechanism requires proteome remodeling accomplished via regulation of protein synthesis as well as degradation, but the global patterns of proteome remodeling and the under...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-03-31 | PXD016004 | Pride
Synaptic plasticity Proteome turnover Dynamic silac Proteome remodelling Homeostatic scaling 
TranscriptomicsDifferential scaling of gene expression with cell size may explain size control in budding yeast.
Yeast cells must grow to a critical size before committing to division. It is unknown how size is measured. We find that as cells grow, mRNAs for some cell cycle activators scale faster than size, increasing in concentration, while mRNAs for some inhibitors scale slower than size, decreasing in conc...
ORGANISM(S): Saccharomyces cerevisiae 
2020-02-16 | GSE145206 | GEO
ProteomicsTime- and Polarity-dependent Proteomic Changes associated with Homeostatic Scaling at Central Synapses
In homeostatic scaling, the cellular mechanisms that detect the offset from the set-point, the duration of the offset and implement a cellular response are not well-understood. To understand the time-dependent dynamics,we manipulated activity for 2 hrs to induce the process of up or down-scaling and...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-02-16 | PXD008271 | Pride
Boncat Proteomics Homeostatic scaling 
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