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TranscriptomicsTranscription profiling of lamb Callipyge muscle types (ST, LD, SS, SM) at birth (T=0) and 12 weeks (T=12)
Microarrays were used for transcription profiling of skeletal muscle samples taken at birth, when the phenotype was not expressed, and 12 weeks of age from Callipyge and wild type sheep. The genes that underlie the expression of the phenotype rather than result from the fibre type change in the affe...
ORGANISM(S): Ovis aries 
2008-11-07 | E-GEOD-5955 | biostudies-arrayexpress
TranscriptomicsMuscle Hypertrophy Induced by Myostatin Inhibition Accelerates Degeneration in Dysferlinopathy
Because myostatin normally limits skeletal muscle growth, there is an extensive effort to develop myostatin inhibitors for clinical use. One potential concern is that in patients with muscle degenerative diseases, inducing hypertrophy may increase stress on dystrophic fibers. Here, we show that bl...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-62945 | biostudies-arrayexpress
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
ProteomicsComparative Proteomic and Transcriptomic Analysis of Follistatin-induced Skeletal Muscle Hypertrophy
Skeletal muscle, the most abundant body’s tissue, plays vital roles in locomotion and metabolism. Myostatin is a negative regulator of skeletal muscle mass. In addition to increase muscle mass, Myostatin inhibition impacts on muscle contractility and energy metabolism. To decipher the mechanisms of ...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-17 | PXD005899 | Pride
Follistatin Mass spectrometry Microarray Skeletal muscle hypertrophy Myostatin 
TranscriptomicsExercise promotes growth and vascularization of fast skeletal muscle by activating myogenic and angiogenic transcriptional programs in adult zebrafish
The adult skeletal muscle is a plastic tissue with a remarkable ability to adapt to different levels of activity by altering its excitability, its contractile and metabolic phenotype and its mass. Knowledge on the mechanisms responsible for muscle mass comes primarily from models of muscle inactivit...
ORGANISM(S): Danio rerio 
2014-12-23 | E-GEOD-58929 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of callipyge lambs at the onset of muscle hypertrophy in : time course
The callipyge mutation causes postnatal muscle hypertrophy in heterozygous lambs that inherit a paternal callipyge allele (+/CLPG). Our hypothesis was that the up-regulation of one or both of the affected paternally expressed genes (DLK1 or PEG11) initiates changes in biochemical and physiological ...
ORGANISM(S): Ovis aries 
2008-11-07 | E-GEOD-5195 | biostudies-arrayexpress
TranscriptomicsEquine skeletal muscle: pre versus post-exercise
Unconditioned thoroughbred geldings were exercised to maximal heart rate or fatigue on an equine high-speed treadmill. Skeletal muscle biopsies were taken from the middle gluteal muscle before, immediately after and four hours after exercise.  Three-condition experiment, Pre exercise (T0), Immediat...
ORGANISM(S): Equus caballus 
2010-06-21 | E-GEOD-16235 | biostudies-arrayexpress
TranscriptomicsThe Mitochondrial Calcium Uniporter controls skeletal muscle mass in vivo
Muscle atrophy contributes to the poor prognosis of many physiopathological conditions, but pharmacological therapies are still limited. Muscle activity leads to major swings in mitochondrial [Ca2+] which control aerobic metabolism, cell death and survival pathways. We have investigated in vivo the ...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-60931 | biostudies-arrayexpress
TranscriptomicsEffect of fasting on human skeletal muscle mRNA levels
The goal of these studies was to determine the effects of fasting on skeletal muscle mRNA levels in healthy human subjects. Seven healthy adult human subjects fasted for 40 hours and then a muscle biopsy (fasting sample) was obtained from the vastus lateralis muscle. Immediately after the first mus...
ORGANISM(S): Homo sapiens 
2011-06-08 | E-GEOD-28016 | biostudies-arrayexpress
TranscriptomicsCluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy
Overall, the widely disparate transcriptomes identified prior to RT among the three clusters support the notion that at least some of the inter-individual heterogeneity in propensity for RT-induced myofiber hypertrophy is likely pre-determined. Baseline comparisons of skeletal muscle transcript prof...
ORGANISM(S): Homo sapiens 
2013-05-24 | E-GEOD-42507 | biostudies-arrayexpress
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