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MetabolomicsExercise-Associated Microbial Metabolites Prevent Skeletal Muscle Atrophy in Adult Mice
We previously reported that skeletal muscle adaptation to regular exercise requires a healthy gut microbiome, contributing to growing evidence that some exercise benefits are mediated by microbiome-derived metabolites. Here, to identify such exercise-associated microbial metabolites, we transfer cec...
2026-05-27 | MTBLS14386 | MetaboLights
MetabolomicsHippophae rhamnoides-Derived Exosome-like Nanovesicles Alleviate Dexamethasone-Induced Sarcopenia by Remodeling Skeletal Muscle Lipid Metabolism
Skeletal muscle atrophy driven by glucocorticoid excess is a clinically relevant contributor to sarcopenia, yet safe and biologically integrated interventions remain limited. Here we report that extracellular exosome-like nanovesicles derived from Hippophae rhamnoides fruits (HR-ELNs) protect agains...
2026-07-17 | MTBLS15070 | MetaboLights
MetabolomicsHost autophagy mediates organ wasting and nutrient mobilization for tumor growth
During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support tumor growth, in part through ...
2021-09-24 | MTBLS2771 | MetaboLights
TranscriptomicsInvolvement of miRNAs in the Regulation of Muscle Wasting during Catabolic Conditions.
Loss of muscle proteins and the consequent weakness has important clinical consequences in diseases such as cancer, diabetes, chronic heart failure and in ageing. In fact, excessive proteolysis causes cachexia, accelerates disease progression and worsens life expectancy. Muscle atrophy involves a co...
ORGANISM(S): Mus musculus 
2014-07-15 | E-GEOD-51648 | biostudies-arrayexpress
MetabolomicsMicrobiome and metabolome patterns centered on cancer cachexia link skeletal muscle and adipose tissue depletion to clinical outcomes in locally advanced rectal cancer

This study employed untargeted serum metabolomics to delineate the specific metabolic landscape of cancer cachexia in patients with locally advanced rectal cancer. By analyzing LC-MS raw data from 133 patients (64 discovery, 69 validation), we identified and validated key cachexia-associated meta...

2026-05-09 | MTBLS13787 | MetaboLights
ProteomicsMarked increased production of acute phase reactants by skeletal muscle during cancer cachexia
Background Loss of skeletal muscle mass in cancer cachexia is recognized as an independent predictor of mortality. Mechanisms involved in this wasting process and parameters for early diagnosis are not yet clearly defined. As skeletal muscle is considered as a secretory organ, the aim of this prese...
ORGANISM(S): Mus Musculus 
2021-01-24 | PXD019433 | panorama
TranscriptomicsGenome-wide analysis of skeletal muscle gene expression in mice with C26 tumor-induced muscle wasting and cachexia
Analysis of gene expression in CD2F1 mice with cancer cachexia due to implantation of C26 colon carcinoma cells. Total RNA obtained from quadriceps muscle of female CD2F1 mice with early weight loss (10%) or severe weight loss (15%) due to intrascapular subcutaneous implantation of one million C26 c...
ORGANISM(S): Mus musculus 
2011-08-29 | E-GEOD-24112 | biostudies-arrayexpress
TranscriptomicsEffect of spermine oxidase overexpression on skeletal muscle mRNA expression.
For additional details see Bongers et al, Spermine Oxidase Maintains Basal Skeletal Muscle Gene Expression and Fiber Size, and Is Strongly Repressed by Conditions that Cause Skeletal Muscle Atrophy . Am J Physiol Endocrinol Metab. 2014 [under review] Bilateral tibialis anterior muscles of C57BL/6 m...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-63006 | biostudies-arrayexpress
TranscriptomicsEffect of p21 overexpression on skeletal muscle mRNA expression.
For additional details see Bongers et al, Spermine Oxidase Maintains Basal Skeletal Muscle Gene Expression and Fiber Size, and Is Strongly Repressed by Conditions that Cause Skeletal Muscle Atrophy . Am J Physiol Endocrinol Metab. 2014 [under review] Bilateral tibialis anterior muscles of C57BL/6 m...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-63007 | biostudies-arrayexpress
ProteomicsGadd45a Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4
Skeletal muscle atrophy is a serious and highly prevalent condition that remains poorly understood at the molecular level. Previous work found that skeletal muscle atrophy involves an increase in skeletal muscle Gadd45a expression, which is necessary and sufficient for skeletal muscle fiber atrophy...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-05-17 | MSV000079730 | MassIVE
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