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TranscriptomicsMisregulation of alternative splicing of BIN1 leads to T-tubule alterations and muscle weakness in myotonic dystrophy
Myotonic dystrophes (DM), the most common adult muscular dystrophy, are the first recognized examples of RNA-mediated diseases in which expression of mutant RNAs containing expanded CUG or CCUG repeats interfere with the splicing of other mRNAs. Using whole-genome microarrays, we found that alternat...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-21795 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis reveals abnormal repair and remodeling in survivors of critical illness with sustained muscle weakness
ICU acquired weakness (ICUAW) is a complication of critical illness characterized by structural and functional impairment of skeletal muscle that may persist for years after ICU discharge with many survivors developing protracted courses with few regaining functional independence. Elucidating molec...
ORGANISM(S): Homo sapiens 
2016-07-18 | E-GEOD-78929 | biostudies-arrayexpress
ProteomicsCircadian rhythm disruption is associated with skeletal muscle dysfunction within the blind Mexican Cavefish
Circadian rhythm disruption is associated with skeletal muscle dysfunction within the blind Mexican Cavefish
ORGANISM(S): Astyanax Mexicanus (ncbitaxon:7994) 
2023-01-13 | MSV000091062 | MassIVE
TranscriptomicsTranscription profiling of skeletal and cardiac muscles in dysferlin-deficient SJL/J mice and wild type mice to understand the protective mechanisms against dysferlin deficiency in cardiac muscles.
Dysferlin is expressed in skeletal and cardiac muscle. However, dysferlin deficiency, namely limb girdle muscular dystrophy 2B (LGMD2B) and Myoshi myopathy, results in skeletal muscle weakness and spares the heart. This dichotomy could be caused by differential regulation of protective mechanisms. T...
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2507 | biostudies-arrayexpress
TranscriptomicsAberrant calcium influx causes fiber type shift and mitochondrial loss in skeletal muscle
Skeletal muscle excitation-contraction (EC) coupling is independent of calcium influx. In fact alternative splicing of the voltage-gated calcium channel CaV1.1 actively suppresses calcium currents in mature muscle. Why this might be necessary is not known. However, splicing defects causing aberrant ...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-67803 | biostudies-arrayexpress
TranscriptomicsSkeletal muscle gene expression data from Down syndrome mice
Persons with Down syndrome (DS) exhibit low muscle strength that significantly impairs their physical functioning. The Ts65Dn mouse model of DS also exhibits muscle weakness in vivo and may serve as a useful model to examine potential factors responsible for DS-associated muscle dysfunction. Therefo...
ORGANISM(S): Mus musculus 
2013-01-06 | E-GEOD-39159 | biostudies-arrayexpress
ProteomicsDysferlin deficient mice proteomics
Investigation of age-dependent changes in the proteomic profile of Dysferlin-deficient mouse skeletal muscle relative to healthy muscle.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-01-04 | MSV000088639 | MassIVE
TranscriptomicsExpression data from young and adult mice after over expression of self MHC class l protein in skeletal muscle.
Over expression of MHC Class l protein in skeletal muscle causes myositis. Phenotype after expression in young mice is more severe. We performed gene expression profiling on young and adult mice after over expression of self MHC class l protein in skeletal muscle Muscle from young ( early) , adult ...
ORGANISM(S): Mus musculus 
2009-06-02 | E-GEOD-14997 | biostudies-arrayexpress
ProteomicsA molecular insight into fluoride toxicity in skeletal muscle using invitro C2C12 and in vivo C57BL/6 mice models
Fluoride toxicity in multiple organs has been extensively reported in several decades of research. In-depth study coverage is available on teeth and bone tissues. But studies addressing skeletal muscle fluorosis are scanty. C57BL/6 mice were provided with sodium fluoride in drinking water for 60 day...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035014 | Pride
Mus musculus Skeletal muscle Sodium fluoride Orbitrap Lc-ms/ms 
TranscriptomicsInvolvement of miRNAs in the Regulation of Muscle Wasting during Catabolic Conditions.
Loss of muscle proteins and the consequent weakness has important clinical consequences in diseases such as cancer, diabetes, chronic heart failure and in ageing. In fact, excessive proteolysis causes cachexia, accelerates disease progression and worsens life expectancy. Muscle atrophy involves a co...
ORGANISM(S): Mus musculus 
2014-07-15 | E-GEOD-51648 | biostudies-arrayexpress
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