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ProteomicsSkin cancer-associated S. aureus downregulates DNA repair mechanisms, and promotes oxidative stress and DNA damage in human keratinocytes
Actinic keratoses (AK) are premalignant lesions common on photo-damaged skin that, over time, can progress to squamous cell carcinoma (SCC). A high bacterial load of Staphylococcus aureus is associated with AK and SCC but it is unknown whether this has a direct impact on skin cancer development. To ...
ORGANISM(S): Staphylococcus Capitis Staphylococcus Aureus Staphylococcus Epidermidis Staphylococcus 
2022-05-17 | PXD031676 | panorama
TranscriptomicsGene expression profiling of sensitive skin
Sensitive skin is a hyperactive skin condtion, characterized by prickling, burning, itching, stinging, pain, or tingling sensation, which develops in response to various internal and external stimulants that can be tolerated by most people. The pathophysiology involved in the development of sensitiv...
ORGANISM(S): Homo sapiens 
2015-11-03 | E-GEOD-48506 | biostudies-arrayexpress
TranscriptomicsMicroarray of reconstructed epidermis from skin models made with cells from African and Caucasian Skin type
The aim of this study was to analyze the in vitro biological epidermal processes occurring in reconstructed skins using cells from breast skin of African and Caucasian skin type color. A exploration of mRNA expression levels in the epidermis of reconstructed skin was undertaken to elucidate the diff...
ORGANISM(S): Homo sapiens 
2020-08-10 | E-MTAB-9433 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human native skin, cultured skin substitute, constituent keratinocytes and fibroblasts to identify gene signatures that are highly characteristic of different tissue types
Cultured skin substitutes, prepared using keratinocytes, fibroblasts and biopolymers, can facilitate closure of massive burn wounds by increasing the availability of autologous tissue for grafting. However, because they contain only two cell types, skin substitutes cannot replace all of the functio...
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3204 | biostudies-arrayexpress
TranscriptomicsscRNAseq of freshly dissociated and cultured skin biopsies
We describe new optimised skin tissue dissociation protocol to digest ex vivo cultured and fresh human skin samples. Using scRNAseq analysis we created skin atlas composition of fresh and cultured skin samples and integrate it with other publicly available skin tissue scRNAdata to compare the qualit...
ORGANISM(S): Homo sapiens 
2022-08-04 | E-MTAB-11509 | biostudies-arrayexpress
TranscriptomicsMurine skin gene expression analysis of skin-specific Scd1-deficient and control mice
To help elucidate the metabolic changes in the skin that contribute to the obesity resistance and skin pathology in mice lacking Scd1, we performed microarray analysis of skin gene expression in male skin Scd1 knockout (SKO) and Scd1 flox/flox control (Lox) mice fed a standard rodent diet. We identi...
ORGANISM(S): Mus musculus 
2011-05-09 | E-GEOD-24243 | biostudies-arrayexpress
TranscriptomicsErbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation.
Exposure to ultraviolet (UV) irradiation is the major cause of nonmelanoma skin cancer, the most common form of cancer in the United States. UV irradiation has a variety of effects on the skin associated with carcinogenesis, including DNA damage and effects on signal transduction. The alterations in...
ORGANISM(S): Mus musculus 
2006-07-01 | E-GEOD-4066 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human grafted engineered skin substitutes compared with intact human
The goal of the experiment: To characterize the dynamic gene expression profile of engineered human skin in vitro and after grafting, and compare with expression profile of uninjured human skin. Bioengineered skin substitutes can facilitate wound closure in massively burned patients, but deficiencie...
ORGANISM(S): Homo sapiens 
2009-09-07 | E-GEOD-17539 | biostudies-arrayexpress
TranscriptomicsSmall RNA sequencing in normal and psoriatic skin
We report the application of Illumina small RNA sequencing to normal human skin, as well as uninvolved and involved psoriatic skin. By obtaining over 600 million qualified reads from 20 healthy controls and 47 psoriasis biopsies (uninvolved/involved), we have generated a complete small RNA profile i...
ORGANISM(S): Homo sapiens 
2011-08-19 | E-GEOD-31037 | biostudies-arrayexpress
TranscriptomicsWhole genome expression data from pre-auricular and post-auricular skin tissues
Photoaging is cumulative damage that is caused by chronic, repeated solar radiation exposure to skin. Its molecular mechanisms are poorly understood at the level of global gene expression.This study set out to uncover genes and functional modules involved in photoaging at the level of transcription,...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-38308 | biostudies-arrayexpress
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