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MetabolomicsSingle-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance
Multi-drug resistance (MDR) is an almost inevitable end point of cancer therapy, driving rapid tumor progression, yet its evolutionary logic remains unclear because MDR tumors are rarely resected. Using paired therapy-naive and MDR melanoma specimens from a clinical trial, integrated with single-cel...
2027-08-13 | MTBLS15322 | MetaboLights
TranscriptomicsTranscription profiling of human native skin, cultured skin substitute, constituent keratinocytes and fibroblasts to identify gene signatures that are highly characteristic of different tissue types
Cultured skin substitutes, prepared using keratinocytes, fibroblasts and biopolymers, can facilitate closure of massive burn wounds by increasing the availability of autologous tissue for grafting. However, because they contain only two cell types, skin substitutes cannot replace all of the functio...
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3204 | biostudies-arrayexpress
TranscriptomicsExpression data from K5-IKKbeta transgenic mouse skin
IKKbeta is a subunit of the IkB kinase (IKK) complex required for NF-kB activation in response to pro-inflammatory signals. NF-kB regulates the expression of many genes involved in inflammation, immunity and apoptosis, and also controls cell proliferation and differentiation in different tissues; ho...
ORGANISM(S): Mus musculus 
2010-03-22 | E-GEOD-17511 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of in vivo immune responses to mycobacteria using the tuberculin skin test
Transcriptional profiling of biopsies from tuberculin skin test sites was performed to investigate the interaction of complex cellular and molecular networks at the interface between innate and adaptive immunity which coordinate anti-mycobacterial responses in vivo.
ORGANISM(S): Homo sapiens 
2012-05-13 | E-TABM-1157 | biostudies-arrayexpress
ProteomicsDiscovery proteomics on cutaneous biopsies
Lyme disease is the most important vector-borne disease in the Northern hemisphere and represents a major public health challenge. The disease diagnosis relies mainly on clinical practice that can be coupled to serological or molecular diagnostics. However the relatively low sensitivity and specific...
ORGANISM(S): Borrelia burgdorferi 297 
2016-07-09 | PXD000879 | Pride
Lyme borreliosis Skin interface Lc-ms/ms 
TranscriptomicsExpression data from human 3D skin models in response to IL-31 treatment
Atopic dermatitis, a chronic inflammatory skin disease with increasing prevalance, is closely associated with skin barrier defects. A cytokine related to disease severity and inhibition of keratinocyte differentiation is IL-31. To identify its molecular targets, IL-31-dependent gene expression was d...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-76880 | biostudies-arrayexpress
TranscriptomicsStem cells rejuvinate the schistosome host-parasite interface
Schistosomes infect more than 200 million of the world's poorest people. These parasites live in the vasculature, producing eggs that spur a variety of chronic, potentially life-threatening, pathologies exacerbated by the long lifespan of schistosomes, that can thrive in the host for decades. How sc...
ORGANISM(S): Schistosoma mansoni 
2015-12-10 | E-GEOD-75861 | biostudies-arrayexpress
ProteomicsLarge yellow croaker skin mucus proteome
Proteomics data demonstrate that skin mucus of the air-exposed large yellow croaker had a complex composition, with an unexpectedly high number of proteins (3,209), suggesting its multiple protective mechanisms possibly involved in antioxidant functions, oxygen transport, immune defence, and osmot...
ORGANISM(S): Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea) 
2015-04-17 | PXD001218 | Pride
Larimichthys crocea  skin mucus air exposure lc–ms/ms Large yellow croaker 
ProteomicsMicrodialysis analysis of common inflammatory skin diseases highlights abnormalities in nonlesional skin of patients with atopic dermatitis
Insight into the pathophysiology of inflammatory skin diseases, especially at the proteomic level, is severely hampered by the lack of adequate in situ data. Skin microdialysis samples from patients with atopic dermatitis (AD, n=6), psoriasis vulgaris (PSO, n=7) or prurigo nodularis (PN, n=6), as we...
ORGANISM(S): Homo sapiens (Human) 
2024-08-22 | PXD050245 | Pride
Microdialysis Psoriasis vulgaris Atopic dermatitis Pruritus 
MetabolomicsSurvival, gene and metabolite responses of Litoria verreauxii alpina frogs to fungal disease chytridiomycosis
The fungal skin disease chytridiomycosis has caused the devastating decline and extinction of hundreds of amphibian species globally, yet the potential for evolving resistance, and the underlying pathophysiological mechanisms remain poorly understood. We exposed 406 naïve, captive-raised alpine tree...
2018-01-09 | MTBLS457 | MetaboLights
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