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TranscriptomicsComparisons of the global gene profile between C-CPE treated- and untreated- SKOV-3 ovarian cancer cells.
A microarray analysis was performed to compare the global gene expression profile between C-CPE treated- and untreated- SKOV-3 ovarian cancer cells. SKOV-3 cells were treated with or without C-CPE for 72 hours, and total RNA was extracted and microarray was perfomed to compare the gene profiling cha...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-22421 | biostudies-arrayexpress
TranscriptomicsOffect of ATP depletion on SKOV-3 cells using apyrase
The purpose of this experiment was to identify the effects of ATP depletion (using apyrase) on a metastatic ovarian carcinoma cell line (SKOV-3) and compare it to a non-treated sample. Cells were treated either with media alone or with media with apyrase during 24h. SKOV-3 cells were harvested durin...
ORGANISM(S): Homo sapiens 
2023-12-31 | E-MTAB-13598 | biostudies-arrayexpress
ProteomicsInward outward signaling in ovarian cancer: morpho-proteomics/phosphoproteomics profiling upon hypoxia and shear stress characterizes the adaptive potential of OVCAR-3 and SKOV-3 cells
With the onset of resistance, ovarian cancer cells display almost unpredictable adaptive potential. This may derive from genetic ancestry of the tumor cells and can be additionally tailored by post translational protein modifications (PTMs). The latter are profoundly shaped by the physical and chemi...
ORGANISM(S): Homo sapiens (Human) 
2022-01-13 | PXD027466 | Pride
Hypoxia Vasculogenic mimicry Fluid shear stress Morpho-metabolic adaptation Ovarian cancer 
TranscriptomicsAffymetrix GeneChip® human gene 2.0 ST array analysis of SKOV-3 human ovarian cancer cells following siRNA knockdown of MAD2 or TLR4 compared to cells transfected with scrambled negative control siRNAs.
Both TLR4 and MAD2 are biomarkers associated with paclitaxel resistance in ovarian cancer. Therefore we performed microarray analysis following knockdown of each marker in SKOV-3 cells to gain greater insight into key downstream pathways that these biomarkers activate and also determine any potenti...
ORGANISM(S): Homo sapiens 
2020-12-06 | E-MTAB-8440 | biostudies-arrayexpress
TranscriptomicsSKOV-3TR
Human paclitaxel-resistant (SKOV-3TR) ovarian cancer cell line and the parent SKOV-3 cell line were grown in RPMI medium containing 10% fetal calf serum. The experiment was done to compare the expression differences between the parent SKOV-3 cell line and the derived SKOV-3TR cell line. Cells were ...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-2627 | biostudies-arrayexpress
ProteomicsIntegration of two in-depth proteomics approaches determines the high grade serous ovarian cancer-associated kallikrein-related peptidase 7 (KLK7) degradome
Kallikrein-related peptidase 7 (KLK7) is a serine peptidase that is over-produced in the most lethal form of ovarian cancer, called high grade serous ovarian cancer (HGSOC). To determine its underlying molecular mechanism of action, a comprehensive analysis of KLK7 degradome in the SKOV-3 cell-secre...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD003752 | Pride
Transcriptome Matrix metalloprotease Thrombospondin Protease Extracellular Degradome Substrate Omics Microenvironment Ovarian cancer High-grade serous Kallikrein-related peptidase Tumour 
UnknownBiocompatible supramolecular pseudorotaxane hydrogels for controllable release of doxorubicin in ovarian cancer SKOV-3 cells.
Not available
S-EPMC9048191 | biostudies-literature
UnknownHyperglycemia-Associated Dysregulation of O-GlcNAcylation and HIF1A Reduces Anticancer Action of Metformin in Ovarian Cancer Cells (SKOV-3).
Not available
S-EPMC6163973 | biostudies-literature
TranscriptomicsTranscriptome analysis on ovarian cancer
We are studying signaling pathways and growth properties of cultured human ovarian cancer cells that are expressing the G protein-coupled receptor, luteinizing hormone receptor (LHR),particularly interested in the changes that occur when the receptor is activated by its cognate ligand, gonadotropin ...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-27328 | biostudies-arrayexpress
UnknownH-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer.
Not available
S-EPMC2230112 | biostudies-literature
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