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GenomicsRequired Enhancer: Matrin-3 Structure Interactions for Homeodomain Transcription Programs
Study of the POU-homeodomain transcription factor, has revealed that, binding of Pit1-occupied enhancers to a nuclear matrin-3-rich network/architecture is a key event in effective activation of the Pit1-regulated enhancer / coding gene transcriptional program. All ChIP-seq(s) were designed to under...
ORGANISM(S): Rattus norvegicus 
2014-08-03 | E-GEOD-58009 | biostudies-arrayexpress
ProteomicsPolyunsaturated Fatty Acid - mediated Cellular Rejuvenation for Restoration of Vision in Aging
The retina is uniquely enriched in polyunsaturated fatty acids (PUFAs), which are primarily localized in cell membranes, where they govern membrane biophysical properties such as diffusion, permeability, domain formation, and curvature generation. During aging, alterations in lipid metabolism lead t...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-02 | PXD066430 | Pride
Vlc-pufa Lipid supplementation Pufa Amd Elovl2 Aging 
GenomicsEnhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program [ChIP-seq]
Substantial evidence supports the hypothesis that enhancers are critical regulators of cell type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and re...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-64483 | biostudies-arrayexpress
TranscriptomicsEnhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program [GRO-seq]
Substantial evidence supports the hypothesis that enhancers are critical regulators of cell type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and re...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-64515 | biostudies-arrayexpress
TranscriptomicsA positive feedback loop between Atoh7 and a Notch effector regulates cell cycle progression and neurogenesis in retina
The microarray analysis was designed to test the effects of HES5.3 siRNAs, Atoh7 siRNAs and nt siRNAs on gene expression in embryonic chick retina.
ORGANISM(S): Gallus gallus 
2013-03-01 | E-MTAB-1430 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chicken whole eye and retinal ganglion cells (RGC) to identify RGC-specific genes
Identification of genes regulated by ATH5 in a dose-dependent manner.; Identification of retinal ganglion cells (RGC)-specific genes.
ORGANISM(S): Gallus gallus 
2009-01-14 | E-TABM-417 | biostudies-arrayexpress
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