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MetabolomicsEMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer

The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. We show that two SLCs from the organic anion...

2021-10-15 | MTBLS1925 | MetaboLights
ProteomicsIlluminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates
HEK293 Flp-In cells were transfected transiently with various SLC22A10 orthologs, including human, chimpanzee, and the mutations to proline or leucine at position 220. After 72 hours of transfection, cell pellets were collected. The quantification was performed on both HEK293 cells and HEK293cells e...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD047102 | Pride
Hek293 Slc22a10 Lc-ms/ms 
UnknownIlluminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
Not available
S-EPMC10441401 | biostudies-literature
UnknownIlluminating the function of the orphan transporter, SLC22A10, in humans and other primates.
Not available
S-EPMC11116522 | biostudies-literature
UnknownEMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
Not available
S-EPMC9036131 | biostudies-literature
UnknownRare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer's disease CSF profile of neuronal injury and inflammation.
Not available
S-EPMC9126805 | biostudies-literature
GenomicsTranscriptomic alterations in stably overexpressing (OE) clones of solute carriers SLC22A10 and SLC22A15 in PANC-1 (human pancreatic cancer cell line)
Transcriptomic alterations in stably overexpressing (OE) clones of solute carriers SLC22A10 and SLC22A15 in PANC-1 (human pancreatic cancer cell line)
PRJNA656196 | ENA
UnknownIdentification of special key genes for alcohol-related hepatocellular carcinoma through bioinformatic analysis.
Not available
S-EPMC6368834 | biostudies-literature
TranscriptomicsTranscriptomic alterations in stably overexpressing (OE) clones of solute carriers SLC22A10 and SLC22A15 in PANC-1 (human pancreatic cancer cell line)
We conducted RNA-seq analysis of vector (control), SLC22A10_OE and SLC22A15_OE clones to identify any SLC22-specific oncogenic alterations associated with pancreatic cancer progression. Our findings demonstrate substantial activation of key regulators of epithelial-mesenchymal transition (EMT), canc...
ORGANISM(S): Homo sapiens 
2021-05-31 | GSE155909 | GEO
UnknownSystems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs.
Not available
S-EPMC7084758 | biostudies-literature
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