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TranscriptomicsTranscriptome changes in Slc7a5-null mouse embryos
The effects of loss of the large neutral amino acid transporter Slc7a5 (aka Lat1) on mouse embryonic development were investigated. Slc7a5 fl/fl mice harbouring two copies of the Slc7a5 targeted allele (exon 1 of Slc7a5 flanked with two loxP sites), were crossed with a mouse line ubiquitously expres...
ORGANISM(S): Mus musculus 
2019-06-01 | E-MTAB-6336 | biostudies-arrayexpress
GenomicsTranscriptome changes in Slc7a5-null mouse embryos
Transcriptome changes in Slc7a5-null mouse embryos
PRJEB24323 | ENA
ProteomicsProteome of naive and TCR activated wild-type, Myc-deficient and Slc7a5-deficient T cells
T cell clonal expansion and differentiation are critically dependent on the transcription factor c-Myc (Myc). Herein we use quantitative mass-spectrometry to reveal how Myc controls antigen receptor driven cell growth and proteome restructuring in CD4+ and CD8+ T cells. Quantitative proteomics was p...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-25 | PXD016105 | Pride
Lc-msms Mouse T lymphocyte Myc Slc7a5 Amino acid transport 
GenomicsSLC7A5 is critical for Paneth cell integrity and function
SLC7A5 is critical for Paneth cell integrity and function
PRJNA896198 | ENA
MetabolomicsLarge neutral amino acid levels tune perinatal neuronal excitability and survival
Surprisingly little is known about the critical metabolic changes that neural cells have to undergo during development and how even mild, temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically-...
2023-03-28 | MTBLS6578 | MetaboLights
ProteomicsYBX3 is a versatile RNA-binding protein that controls amino acid import by regulating SLC mRNA abundance
Summary: Amino acids (AA) support protein synthesis, and thus cell growth and proliferation. Specialized transporters mediate AA exchange across membranes and their regulation is critical for AA homeostasis. Here, we report that the DNA- and RNA-binding protein YBX3 regulates the expression of AA t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-06 | MSV000083108 | MassIVE
TranscriptomicsSLC7A5-overexpression NK cell and SLC7A5-overexpression induced pluripotent stem cell-derived NK cells(iPSC-NK)
This dataset contains RNA-sequencing data from human induced pluripotent stem cell-derived natural killer (iPSC-NK) cells with or without SLC7A5 overexpression. The study was designed to investigate transcriptional changes associated with SLC7A5-mediated metabolic engineering in iPSC-NK cells, with ...
ORGANISM(S): Homo sapiens 
2026-09-01 | GSE344838 | GEO
GenomicsTumor-Infiltrating CTL expansion and effector functions depends on Slc7a5-dependent tryptophan update [scRNA-seq]
Tumor-Infiltrating CTL expansion and effector functions depends on Slc7a5-dependent tryptophan update [scRNA-seq]
PRJNA1113354 | ENA
GenomicsTumor-Infiltrating CTL expansion and effector functions depends on Slc7a5-dependent tryptophan update [RNA-seq]
Tumor-Infiltrating CTL expansion and effector functions depends on Slc7a5-dependent tryptophan update [RNA-seq]
PRJNA1113352 | ENA
GenomicsTumor-Infiltrating CTL expansion and effector functions depends on Slc7a5-dependent tryptophan update [ATAC-seq]
Tumor-Infiltrating CTL expansion and effector functions depends on Slc7a5-dependent tryptophan update [ATAC-seq]
PRJNA1113351 | ENA
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