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TranscriptomicsThe effect of growth rate on pyrazinamide activity in Mycobacterium tuberculosis; insights for early bactericidal activity
Background: Pyrazinamide (PZA) plays an essential part in the shortened 6-month tuberculosis (TB) treatment course due to its activity against slow-growing, semi-dormant organisms. We tested the paradigm that PZA preferentially targets slow growing cells of Mycobacterium tuberculosis that remain aft...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2016-03-25 | E-MTAB-4093 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E. coli K-12 W3110 strain grown at Ph5.7, 7.0, 8.5 reveals pH and anaerobiosis coregulate metabolism, multidrug transporters, and envelope composition
In Escherichia coli, pH-dependent gene expression varies with oxygen level. Anaerobic pH-dependent expression ratios were analyzed and compared to the published analysis of aerated cultures (Maurer et al, 2005). E. coli K-12 strain W3110 was cultured in closed tubes containing LBK broth buffered a...
ORGANISM(S): Escherichia coli 
2008-06-13 | E-GEOD-4556 | biostudies-arrayexpress
ProteomicsStructural Insights into the Role of the Proline Rich Region in Tau Function
Tau is a microtubule-associated protein that plays an important role in modulating axonal microtubules in neurons. Intracellular tau aggregates are found in a broad class of disorders, including Alzheimer’s disease, termed tauopathies. Tau is an intrinsically disordered protein, and its structural d...
ORGANISM(S): Escherichia coli 
2025-01-31 | PXD059518 | Pride
Post-translational modifications Alzheimer's disease Tubulin Tau Phosphorylation Microtubules Aggregation 
UnknownNovel mutations widen the phenotypic spectrum of slow skeletal/β-cardiac myosin (MYH7) distal myopathy.
Not available
S-EPMC4112555 | biostudies-literature
TranscriptomicsTranscriptomic analysis of TLR4 pathways in a murine model of chronic pulmonary inflammation and carcinogenesis
Toll like receptor 4 (TLR4), an innate immunity gene, is involved in responses to several pulmonary agonists including endotoxin (LPS; Poltorak et al.,1998), ozone (O3 ,Kleeberger et. al., 2001), Pseudomonas aeruginosa (Faure et al, 2004), and hyperoxia (Zhang et al, 2005). TLR4 appears to partially...
ORGANISM(S): Mus musculus 
2009-12-12 | E-GEOD-8504 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rats treated with chronic doses of anti-epilepsy drugs to identify genes involved in epileptogenesis
Epilepsy is a major neurological disorder that affects approximately 1% of the population. The processes that lead to the development of epilepsy (epileptogenesis) are largely unknown. Levetiracetam is a novel antiepileptic drug (AED) that in the kindling model inhibits epileptogenesis in addition t...
ORGANISM(S): Rattus norvegicus 
2007-08-01 | E-GEOD-2880 | biostudies-arrayexpress
TranscriptomicsChronic ethanol exposure results in time and brain-region dependent changes in gene coexpression networks.
We examined global gene expression profiles in amygdala (AMY), nucleus accumbens (NAC), prefrontal cortex (PFC) and Liver of male C57BL/6J mice exposed to 4 cycles of chronic intermittent ethanol (CIE) vapor. Animals were sacrificed at 0, 8, and 120 hr following the last ethanol exposure. Mice were ...
ORGANISM(S): Mus musculus 
2015-05-26 | E-GEOD-60676 | biostudies-arrayexpress
TranscriptomicsComparison of naïve, postmitotic (CD44-lo/CD62L-hi) and effector (CD44-hi/CD62L-lo) CD8+ Tcells during BMT in GVHD mice
Naïve CD44-lo/CD62L-hi/CD8+ T cells from C3H.SW mice were compared to CD44-hi/CD82L-lo/CD8+ effector memory T cells and CD44-lo/CD62L-hi/CD8+ postmitotic T cells, using 3 biological replicates of each type of sample. The later two cells types were highly purified at day 14 after transplantation fr...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-13743 | biostudies-arrayexpress
UnknownBeta-hydroxy beta-methylbutyrate/arginine/glutamine (HMB/Arg/Gln) supplementation to improve the management of cachexia in patients with advanced lung cancer: an open-label, multicentre, randomised, controlled phase II trial (NOURISH).
Not available
S-EPMC8274132 | biostudies-literature
TranscriptomicsGene expression analysis during acute hepatitis C virus infection associates dendritic cell activation with viral clearance
Background and Aims: Viral clearance during acute hepatitis C virus (HCV) infection is associated with the induction of potent antiviral T-cell responses. Since dendritic cells (DC) are essential in the activation of primary T-cell responses our goal was to analyze gene expression in DC from patient...
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-65123 | biostudies-arrayexpress
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