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UnknownThe mechanosensitive channel of small conductance (MscS) functions as a Jack-in-the box.
Not available
S-EPMC4259861 | biostudies-literature
UnknownThe BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer.
Not available
S-EPMC5065110 | biostudies-literature
ProteomicsComparative exoproteome profiling of an invasive and a commensal Staphylococcus haemolyticus isolate
Staphylococcus haemolyticus is a skin commensal emerging as an opportunistic pathogen. Nosocomial isolates of S. haemolyticus are the most antibiotic resistant members of the coagulase negative staphylococci (CoNS), but information about other S.haemolyticus virulence factors is scarce. Bacterial vi...
ORGANISM(S): Staphylococcus haemolyticus 
2018-11-30 | PXD010389 | Pride
Staphylococcus haemolyticus Membrane vesicles Secretome. 
ProteomicsLarge-scale secretome analyses unveil a superior immunosuppressive phenotype from umbilical cord stromal cells compared to other adult mesenchymal stromal cells
Mesenchymal stromal cells (MSCs) with regenerative and immunomodulatory potential are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express a wide variety of bioactive molecules including cytokines, trophic factors, and proteases, which act in a paracrine fashion to ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-29 | PXD011762 | Pride
Chondrocytes Adult stromal cells Umbilical cord stromal cells Lfq Secretome and immunomodulation 
TranscriptomicsTranscription profiling of Drosophila exposed to a levitation magnet for different lengths of time
Drosophila samples were exposed to the levitation magnet inside a 25mm diameter tubes with 3 ml of yeast-based Drosophila food in the bottom and a chamber of only 5 mm of height over the food. This small region is needed in order to guarantee that all the flies were located in the effective g area s...
ORGANISM(S): Drosophila melanogaster 
2010-07-01 | E-MEXP-2082 | biostudies-arrayexpress
UnknownSHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors.
Not available
S-EPMC6343825 | biostudies-literature
UnknownInterfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
Not available
S-EPMC7533678 | biostudies-literature
GenomicsRecurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Follicular lymphoma (FL) is an incurable B-cell malignancy characterized by the t(14;18) and mutations in one or more components of the epigenome. Whilst frequent gene mutations in signaling pathways, including JAK-STAT, NOTCH and NF-κB, have also been defined, the spectrum of these mutations typic...
EGAS00001001190 | EGA
UnknownComplexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA Study.
Not available
S-EPMC2679055 | biostudies-literature
GenomicsOsmotic stress induces phosphorylation of histone H3 at threonine 3 in pericentromeric regions of Arabidopsis thaliana [ChIP-Seq]
Histone phosphorylation plays key roles in stress-induced transcriptional reprogramming in metazoans but its function(s) in land plants has remained relatively unexplored. Here we report that an Arabidopsis mutant defective in At3g03940 and At5g18190, encoding closely related Ser/Thr protein kinases...
ORGANISM(S): Arabidopsis thaliana 
2015-07-22 | E-GEOD-68370 | biostudies-arrayexpress
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