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TranscriptomicsSmall RNA pyrosequencing in the protozoan parasite Entamoeba histolytica reveals strain-specific small RNAs that target virulence genes
We provided a full spectrum analysis for E. histolytica AGO2-2 associated 27nt small RNAs. Additionally, comparative analysis of small RNA populations from virulent and non-virulent amebic strains indicates that small RNA populations may regulate virulence genes. AGO2-2 bound small RNAs from E. hist...
ORGANISM(S): Entamoeba histolytica 
2013-01-24 | E-GEOD-43668 | biostudies-arrayexpress
TranscriptomicsCigarette Smoking Induces Small Airway Epithelial Epigenetic Changes with Corresponding Modulation of Gene Expression
The small airway epithelium (SAE), the first site of smoking-induced lung pathology, exhibits genome-wide changes in gene expression in response to cigarette smoking. Based on the increasing evidence that the epigenome can respond to external stimuli in a rapid manner, we assessed the SAE of smokers...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-43079 | biostudies-arrayexpress
ProteomicsMapping the Proteoform Landscape of Five Human Tissues
Untargeted top-down LC-MS and CZE-MS of five human tissues (kidney, lung, spleen, small intestine, and heart)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-14 | MSV000088565 | MassIVE
ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
GenomicsComprehensive genomic profiles of small cell lung cancer
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. We found bi-allelic inactivation of TP53 and RB1 in nearly all the tumors analyzed, sometimes by complex genomic rearrangements. Two tumors with wild-type RB1 had evidence of chromothripsis leadi...
EGAS00001000925 | EGA
TranscriptomicsDysregulation of microRNAs in neurodegeneration
This dataset contains small RNA-seq data from six Alzheimer disease, three tangle-predominant dementia and seven control brains. Total RNA was isolated from human post-mortem autopsy brain and small RNA-seq was performed as described [Hafner, M., Renwick, N., Brown, M., Mihailovic, A., Holoch, D., L...
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-63501 | biostudies-arrayexpress
ProteomicsLC7 Proteomic Analysis of Matched Control and NSCLC Lung Adenocarcinoma Tissue.
Non-small cell lung adenocarcinoma is the most frequently diagnosed lung cancer type and remains the leading cause of cancer mortality for men and women in the United States. Management of lung cancer is hindered by high false-positive rates due to the inability to resolve benign versus malignant tu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080825 | MassIVE
TranscriptomicsBiologic Phenotyping of the Human Small Airway Epithelial Response to Cigarette Smoking
The first changes associated with smoking are in the small airway epithelium (SAE). Given that smoking alters SAE gene expression, but only a fraction of smokers develop chronic obstructive pulmonary disease (COPD), we hypothesized that assessment of SAE genome-wide gene expression would permit biol...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-11784 | biostudies-arrayexpress
GenomicsSCLC_SNP_6.0 - samples
SNP 6.0 arrays of small cell lung cancer
EGAD00010000558 | EGA
ModelsThiele2013 - Small intestine glandular cells
Thiele2013 - Small intestine glandular cells The model of small intestine glandular cells metabolism is derived from the community-driven global reconstruction of human metabolism (version 2.02, MODEL1109130000 ). This model is desc...
2005-01-01 | MODEL1310110020 | BioModels
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