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TranscriptomicsBowel miRNA expression profiles of infants with gastrointestinal conditions
We have employed miRNA microarray expression profiling to identify miRNA differentially expressed in neonatal bowel tissues with different gastrointestinal conditions. Bowel tissues were collected from infants who underwent surgery treatment for necrotizing enterocolitis (NEC), spontaneous intestina...
ORGANISM(S): Homo sapiens 
2015-08-24 | E-GEOD-68054 | biostudies-arrayexpress
ProteomicsClinical and Proteomic Predictors of Primary Response to Infliximab in Crohn’s Disease with Small Bowel Involvement: A Pilot Study in China
Background and Aim: Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract. Although various biomarkers have been used to predict infliximab (IFX) response in CD, its efficacy in patients with small bowel involvement remains underexplored. This study combined clinical ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-26 | PXD076080 | Pride
Prediction model Small bowel involvement Primary non-response Proteomics Infliximab Crohn’s disease 
ProteomicsLabel free-DDA nano-LC/MS/MS analysis of Human Mesenteric lymph collected from Inflammatory Bowel Disease (IBD) subjects.
Compromise of the intestinal barrier have been associated with a series of inflammatory conditions where the routine controls nutrient absorption and pathogens exclusion is lost to different degrees. The intestinal epithelial cells form a barrier of selective permeability which protects from invasio...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD044801 | Pride
Lable free-dda Lymphatics Inflammatory bowel disease Lymph 
UnknownDiagnostic significance of mesenteric lymph node involvement in proximal small bowel Crohn's disease.
Not available
S-EPMC9403447 | biostudies-literature
TranscriptomicsGenetic and immunohistochemical analysis in a case of pleuropulmonary blastoma with renal tumor and small bowel polyps
The genetic cause for PPB in association with renal tumor and small bowel polyps remains to be identified. Activation of components of the mTOR signalling pathway in the disease lesions suggests that this signal transduction route may be involved in disease pathogenesis and that rapamycin, an inhibi...
ORGANISM(S): Homo sapiens 
2010-04-02 | E-GEOD-15521 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of jejunums from wild type and Klf9-/- mice to investigate the involvement of Klf9 in small intestine crypt-villus cell renewal and lineage determination.
Kruppel-like factor 9 (Klf9), a zinc-finger transcription factor, is implicated in the control of cell proliferation, cell differentiation and cell fate in brain and uterus. Using Klf9 null mutant mice, we have investigated the involvement of Klf9 in small intestine crypt-villus cell renewal and li...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6443 | biostudies-arrayexpress
TranscriptomicsStructural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Colon data]
By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body i...
ORGANISM(S): Mus musculus 
2012-09-03 | E-GEOD-39973 | biostudies-arrayexpress
UnknownDemographics and clinical features associated with abnormal small bowel motility in systemic sclerosis.
Not available
S-EPMC12048077 | biostudies-literature
TranscriptomicsGene expression analysis of IL-17 induced mice small intestinal smooth muscle strips with or without 6-shogaol.
The etiology of post-inflammatory gastrointestinal (GI) motility dysfunction, after resolution of acute symptoms of inflammatory bowel diseases (IBD) and intestinal infection, is largely unknown. Here, using an established mouse model of experimental enteritis, we show that enhancement of smooth mus...
ORGANISM(S): Mus musculus 
2012-09-15 | E-GEOD-39573 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling in colorectal cancer highlights miR-1 involvement in MET-dependent proliferation
Abstract: Altered expression of microRNAs (miRNAs) is associated with development and progression of various human cancers by regulating the translation of oncogenes and tumor suppressor genes. In colorectal cancer (CRC), these regulators complement the Vogelstein multi-step model of pathogenesis an...
ORGANISM(S): Homo sapiens 
2012-02-22 | E-GEOD-28364 | biostudies-arrayexpress
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