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MetabolomicsA Prototypic Small Molecule Database for Bronchoalveolar Lavage-Based Metabolomics
The analysis of bronchoalveolar lavage fluid (BALF) using mass spectrometry-based metabolomics can provide insight into lung diseases, such as asthma. However, the important step of compound identification is hindered by the lack of a small molecule database that is specific for BALF. Here we descri...
2018-02-09 | MTBLS591 | MetaboLights
MetabolomicsDifferential analysis of physicochemical properties and small molecule metabolites in glutinous and non-glutinous sorghum
In this study, using 2 glutinous sorghum and 2 non-glutinous sorghum as research objects, and their differences in grain appearance color, peel thickness, starch structure and small molecule metabolites were analyzed and compared. The results showed that the grain of 2 glutinous sorghum was red, and...
2024-11-28 | MTBLS11382 | MetaboLights
MetabolomicsSmall molecule produced by Photorhabdus interferes with ubiquinone biosynthesis in Gram-negative bacteria

We report identification of 3,6-dihydroxy-1,2-benzisoxazole (DHB) in a screen of Photorhabdus and Xenorhabdus, whose symbiotic relationship with eukaryotic nematodes favors secondary metabolites that meet several requirements matching those for clinically useful antibiotics. DHB is produced by Ph...

2024-09-06 | MTBLS10720 | MetaboLights
MetabolomicsSmall molecule signatures of mice lacking T-cell p38 alternate activation, a model for immunosuppression conditions, after exposure to total body radiation (part II)
Not available
ORGANISM(S): Mus musculus 
ST001892 | MetabolomicsWorkbench
MetabolomicsSmall molecule signatures of mice lacking T-cell p38 alternate activation, a model for immunosuppression conditions, after exposure to total body radiation (part I)
Not available
ORGANISM(S): Mus musculus 
ST001891 | MetabolomicsWorkbench
Proteomicsidentification of the protein targets of a small molecule
Mass spectrometry-based chemical proteomic approaches using limited proteolysis for analysis of the interactions between a small molecule and its protein target(s). DARTS (Drug Affinity Responsive Target Stability) has been used in this study on Hela cell lysate. Ubiquitin carboxyl-terminal hydrolas...
ORGANISM(S): Homo sapiens (Human) 
2024-01-15 | PXD048098 | Pride
Hela cells Orbitrap Lysate Lc-ms/ms 
MetabolomicsPROMIS, global analysis of PROtein-Metabolite Interactions using Size separation in Arabidopsis thaliana
Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
TranscriptomicsInducing pluripotency from mouse somatic cells by small-molecule compounds [RNA-Seq]
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource for regenerative medicine. However, genetic manipulation and difficult-to-manufacture strategies used in reprogramming limit their clinical applications. Here, we show pluripotency can be induced from mous...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-48252 | biostudies-arrayexpress
ProteomicsMembrane-Based Affinity Purification to Identify Target Proteins of a Small-Molecule Drug
We employ MaxLFQ to relatively quantify fold changes of proteins in two groups.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-27 | MSV000085483 | MassIVE
GenomicsIdentification of covalent small-molecule inhibitors of STING
Identification of covalent small-molecule inhibitors of STING
PRJNA454500 | ENA
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