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ProteomicsProteomic Characterization of SMARCA-Deficient Esophageal Adenocarcinoma Reveals Complement Evasion and DNA Repair-Associated Prognostic Subgroups
Background Esophageal adenocarcinoma (EAC) is an aggressive malignancy in which the SWI/SNF catalytic subunits SMARCA2 and SMARCA4 are frequently lost, yet the biological and clinical impact of these deficiencies remains unclear. Methods We analyzed 113 EAC specimens using mass spectrometry–based pr...
ORGANISM(S): Homo sapiens (Human) 
2026-06-25 | PXD074975 | Pride
Esophageal adenocarcinoma  swi/snf complex  proteomics  smarca2  smarca4  complement system  cd55  cd59  dna repair 
UnknownNuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts.
Not available
S-EPMC5854339 | biostudies-literature
ProteomicsA selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
Targeted protein degradation offers an alternative modality to classical inhibition and holds the promise of addressing previously undruggable targets to provide novel therapeutic options for patients. Heterobifunctional molecules co-recruit the target and an E3 ligase, resulting in ubiquitylation ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-20 | PXD032239 | Pride
Protac Tpd Smarca Oral bioavailability 
ProteomicsSMARCA2/4 degradation tails mediate recruitment of two different E3 ligases 
In this work, we characterise novel SMARCA2/4 degraders using a robust cell biology and structural workflow and reveal for the first time, the recruitment of two E3 ligase substrate receptors: FBXO22 and DCAF16 by the same degradation tail. Furthermore, we were able to chemically fine-tune this dual...
ORGANISM(S): Homo sapiens (Human) 
2026-05-16 | PXD065445 | Pride
Smarca2/4 E3 ligases  Protein degrader 
ProteomicsSMARCA2/4 degradation tails mediate recruitment of two different E3 ligases 
In this work, we characterise novel SMARCA2/4 degraders using a robust cell biology and structural workflow and reveal for the first time, the recruitment of two E3 ligase substrate receptors: FBXO22 and DCAF16 by the same degradation tail. Furthermore, we were able to chemically fine-tune this dual...
ORGANISM(S): Homo sapiens (Human) 
2026-05-16 | PXD065523 | Pride
E3 ligases  Smarca2/4 Protein degrader 
GenomicsAndrogen receptor-negative prostate cancer is vulnerable to SWI/SNF-targeting degrader molecules
Androgen receptor-negative prostate cancer is vulnerable to SWI/SNF-targeting degrader molecules
PRJNA1086957 | ENA
GenomicsAndrogen receptor-negative prostate cancer is vulnerable to SWI/SNF-targeting degrader molecules
Androgen receptor-negative prostate cancer is vulnerable to SWI/SNF-targeting degrader molecules
PRJNA1381657 | ENA
ProteomicsHepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication
Hepatitis Delta virus (HDV) is a satellite of Hepatitis B virus with a single stranded circular RNA genome. HDV RNA genome synthesis is carried out in infected cells by cellular RNA polymerases with the assistance of the small hepatitis delta antigen (S-HDAg). Here we show that S-HDAg binds the Brom...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD016880 | Pride
Short linear interaction motif (slim) Hepatitis delta virus (hdv) Snf2h / smarca-5 Snf2l / smarca¬1 Baz2b associated remodeling factor (brf) Rna polymerase ii (rna pol ii) Histone mimicry Hepatitis b virus (hbv) Bromodomain associated to zinc finger protein 2b (baz2b) 
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