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TranscriptomicsBiochemical Efficacy and Safety Trial of Vitamin D: dose-finding, placebo-controlled, randomised clinical trial assessing effects of high dose vitamin D
The overall aim was to investigate the effects of low and high dose vitamin D supplementation on genome-wide gene expression and how this is modulated by genetic variation. We adopted a functional genomics approach to analyse study participants in the BEST-D clinical trial (placebo, low dose or hig...
ORGANISM(S): Homo sapiens 
2018-04-21 | E-MTAB-6246 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ATM +/+, ATM +/- and ATM -/- human lymphoblastoid cell lines exposed to 5 Gy IR at 0, 4 and 24 hours to identify expression phenotypes in Ataxia Telangiectasia carriers and patients
Transcription profiling of ATM (Ataxia Telangiectasia Mutated) +/+ (Control), ATM +/- (AT Carrier) and ATM -/- (AT patient) human lymphoblastoid cell lines exposed to 5 Gy IR at 0, 4 and 24 hours to identify expression phenotypes in Ataxia Telangiectasia carriers and patients
ORGANISM(S): Homo sapiens 
2008-07-29 | E-TABM-321 | biostudies-arrayexpress
UnknownEffects of different modalities of inspiratory muscle training as an add-on to conventional treatment of patients with chronic obstructive pulmonary disease (COPD): study protocol for a randomized controlled trial.
Not available
S-EPMC6480485 | biostudies-literature
UnknownTowards monitoring biodiversity in Amazonian forests: how regular samples capture meso-scale altitudinal variation in 25 km2 plots.
Not available
S-EPMC4149511 | biostudies-literature
UnknownComparative Study of the Structural Features and Electrochemical Properties of Nitrogen-Containing Multi-Walled Carbon Nanotubes after Ion-Beam Irradiation and Hydrochloric Acid Treatment.
Not available
S-EPMC8471838 | biostudies-literature
ProteomicsELMO1 signaling is a promoter of osteoclast function and bone loss
Osteoporosis and bone fractures affect millions of men and women worldwide and are often due to increased bone resorption (bone loss) mediated by osteoclasts. Here, we identify a novel role for the cytoplasmic protein ELMO1 as an important ‘signaling node’ controlling the bone resorption function of...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD023578 | Pride
Bone loss Osteoclasts Elmo1 Gelc-ms 
ProteomicsSerum proteomics and metabolomics reveal the characteristics of the A1762T/G1764A mutations in conjunction with the G1896A mutation.
Background and Objective: CHB is a complex heterogeneous disease with a high incidence and mortality rate. Especially, the mutant strains with A1762T/G1764A and G1896A mutations gradually gained survival advantages during the population evolution process. However, our current understanding of the po...
ORGANISM(S): Homo sapiens (Human) 
2026-04-14 | PXD066939 | Pride
Proteomics Gene mutation Non-targeted metabolomics Genomics analysis Chb 
ProteomicsIdentification of RNA chaperones by gradient profiling in the Lyme disease spirochete, Borrelia burgdorferi
RNA-binding proteins (RBPs) play key roles in regulating gene expression in bacteria. However, relatively few RBPs have been discovered and characterized in Borrelia (Borreliella) burgdorferi, the causative agent of Lyme disease. We utilized gradient profiling to identify putative RBPs that co-sedim...
ORGANISM(S): Borreliella burgdorferi 
2026-06-29 | PXD068462 | Pride
Lyme disease Borrelia burgdorferi Rna chaperone Rna-binding protein 
ProteomicsProteomic Analysis of Affinity-Purified Proteasomes Identifies a Suite of Assembly Chaperones in Arabidopsis
The 26S proteasome is an essential protease for the selective elimination of dysfunctional and short-lived regulatory proteins in eukaryotes. To define the composition of this multi-catalytic, ATP-dependent proteolytic machine in plants, we exploited Arabidopsis particles tagged at either the core ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-09-25 | PXD014610 | Pride
Chaperone  core protease  degradation  proteasome  proteolysis  regulatory particle  ubiquitin 
TranscriptomicsSynthetic Lethal Interaction Between Oncogenic KRAS Dependency and Suppression of STK33 in Human Cancer Cells
Many human oncogenes are challenging therapeutic targets. An alternative to direct targeting of oncogenes is to perform â??synthetic lethalityâ?? screens for genes that are essential only in the context of specific cancer-causing mutations. We used high-throughput RNA interference (RNAi) to identify...
ORGANISM(S): Homo sapiens 
2009-06-24 | E-GEOD-15151 | biostudies-arrayexpress
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