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UnknownA genome-wide association study of marginal zone lymphoma shows association to the HLA region.
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) ...
S-EPMC4287989 | biostudies-literature
UnknownContinuous antiretroviral therapy decreases bone mineral density.

Objectives

To assess the effects of antiretroviral therapy (ART) on bone mineral density (BMD) DESIGN: Randomized comparison of continuous ART (viral suppression group; VS) with intermittent ART (drug conservation group; DC) SETTING: Outpatient clinics in the United States, Australia, and Sp...
S-EPMC2748675 | biostudies-literature
UnknownAn expanded universe of cancer targets.
The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transc...
S-EPMC8066437 | biostudies-literature
UnknownThe effects of intermittent, CD4-guided antiretroviral therapy on body composition and metabolic parameters.

Objective

To assess the effects of decreased antiretroviral therapy exposure on body fat and metabolic parameters.

Design

Substudy of the Strategies for Management of Anti-Retroviral Therapy study, in which participants were randomized to intermittent CD4-guided [Drug Conservation (DC...
S-EPMC2902280 | biostudies-literature
UnknownGenome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.
Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry...
S-EPMC4185120 | biostudies-literature
UnknownGenetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we ...
S-EPMC6763347 | biostudies-literature
UnknownTwo high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenstrom macroglobulinemia.
Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with ...
S-EPMC6180091 | biostudies-literature
UnknownHLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes.
A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of "heterozygote advantage" regarding the role of HLA and NHL, whereby HLA diversity is beneficial and homozygous HLA loci ar...
S-EPMC6065509 | biostudies-literature
UnknownLupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma.

Objective

Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.<...
S-EPMC5715504 | biostudies-literature
UnknownDistinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.
Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide a...
S-EPMC10337695 | biostudies-literature
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