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MetabolomicsMetabolomics analysis reveals the participation of efflux pumps and ornithine in the response of Pseudomonas putida DOT-T1E cells to challenge with propranolol
Efflux pumps are critically important membrane components that play a crucial role in strain tolerance in Pseudomonas putida to antibiotics and aromatic hydrocarbons that result in these toxicants being expelled from the bacteria. Here, the effect of propranolol on P. putida was examined by sudden a...
2016-08-23 | MTBLS320 | MetaboLights
TranscriptomicsMKL1-dependent tenascin-C transcription
The aim of the experiment is to investigate whether megakaryoblastic leukemia factor-1 (MKL1) induces tenascin-C in normal mammary epithelial HC11 and tumor mammary epithelial 4T1 cell lines, as well as to identify other genes that are transcriptionally regulated by MKL1. For this purpose, we compar...
ORGANISM(S): Mus musculus 
2011-06-10 | E-MEXP-3232 | biostudies-arrayexpress
TranscriptomicsPatterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats
The dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wide range of toxic effects in rodent species, all of which are mediated by a ligand-dependent transcription-factor, the aryl hydrocarbon receptor (AHR). The Han/Wistar (Kuopio) (H/W) strain shows exceptional resistance to many ...
ORGANISM(S): Rattus norvegicus 
2011-11-14 | E-GEOD-13513 | biostudies-arrayexpress
TranscriptomicsArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
RELEVANCE: Smith-Lemli-Opitz syndrome (SLOS) is a human disease caused by mutations in the gene coding for the enzyme DHCR7 (7-dehydrocholesterol (7DHC) reductase), which catalyzes the final step of cholesterol biosynthesis. Accumulated 7DHC in tissues and body fluids of SLOS patients gives rise t...
ORGANISM(S): Mus musculus 
2021-03-20 | E-MTAB-10055 | biostudies-arrayexpress
MetabolomicsMetabolic Responses of a Model Green Microalga Euglena gracilis to Different Environmental Stresses

Euglena gracilis, a green microalga known as a potential candidate for jet fuel producers and new functional food resources, is highly tolerant to antibiotics, heavy metals and other environmental stresses. Its cells contain many high-value products, including vitamins, amino acids, pigm...

2022-08-16 | MTBLS2878 | MetaboLights
TranscriptomicsTranscription profiling of Escherichia coli tannin resistance strategies in anaerobic conditions
Gene expression profiles of Escherichia coli, grown anaerobically, with or without Acacia mearnsii (Black wattle) extract were compared to identify tannin-resistance strategies. The cell envelope stress protein, spy, and the multidrug transporter-encoding mdtABCD, both under the control of the BaeSR...
ORGANISM(S): Escherichia coli 
2008-06-16 | E-GEOD-9755 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis carbohydrate metabolism through the diurnal cycle
This proposal is aimed at providing transcriptome data to underpin a long-term joint research programme of Steve Smith and Alison Smith. We are jointly studying starch synthesis and breakdown in Arabidopsis leaves, and individually studying other enzymes of carbohydrate metabolism (eg. sucrose synth...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6174 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis through the diurnal cycle, time series
This proposal is aimed at providing transcriptome data to underpin a long-term joint research programme of Steve Smith and Alison Smith. We are jointly studying starch synthesis and breakdown in Arabidopsis leaves, and individually studying other enzymes of carbohydrate metabolism (eg. sucrose synth...
ORGANISM(S): Arabidopsis thaliana 
2005-02-16 | E-NASC-49 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and hog1 Candida albicans subjected to environmental stresses that are known to activate the Hog1 Stress-activated Protein Kinase
Based on studies in S. pombe (Chen et al., 2003), we predicted that conditions which activate C. albicans Hog1 would result in the induction of a common set of genes that are regulated by this SAPK (Smith et al., 2004). Hence in this study we compared the global transcriptional responses of wild-typ...
ORGANISM(S): Candida albicans 
2007-07-05 | E-MEXP-1134 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver to identify the effect of intermittent hypoxia on gene expression in the liver of ob/ob mice
All animals were kept in a controlled environment (22-24 °C with a 12 h : 12 h light : dark cycle; lights on at 09.00) on a standard chow diet with free access to water. Five ob/ob mice (sample_ids GSM32865-GSM32869) were placed in the intermittent hypoxia (IH) chamber and subjected to IH for 12 con...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-1873 | biostudies-arrayexpress
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