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TranscriptomicsAn Invasive Gene Expression Signature in Pancreas Cancer
Gene expression profiling has demonstrated clinical utility as a predictive tool in clinical oncology. We have identified genes associated with invasion of pancreatic cancer, and with potential for identifying early recurrence. We used Affymetrix Human U133 Plus 2.0 microarrays to identify specific ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-22973 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of individual human oocytes and embryos
Early development in humans is characterised by low and variable embryonic viability, reflected in low fecundity and high rates of miscarriage, relative to other mammals. Data from assisted reproduction programmes provides additional evidence that this is largely mediated at the level of embryonic ...
ORGANISM(S): Homo sapiens 
2013-12-13 | E-MEXP-3870 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Streptomyces coelicolor wild type and phP-null mutants at different time points during phosphate starvation
S. coelicolor was grown in low-phosphate concentration R5 liquid medium which facilitated the transition to a phosphate starvation induced stationary phase and the subsequent induction of the PhoP regulon. Global gene expression profiling of a wild-type and a phoP-null mutant was performed using sam...
ORGANISM(S): Streptomyces coelicolor 
2012-08-30 | E-MAXD-51 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of Streptomyces coelicolor wild type and phP-null mutants during phosphate starvation to determine binding locations of PhoP
S. coelicolor was grown in low-phosphate concentration R5 liquid medium which facilitated the transition to a phosphate starvation induced stationary phase and the subsequent induction of the PhoP regulon. The genome wide binding locations of PhoP during phosphate starvation were determined by chrom...
ORGANISM(S): Streptomyces coelicolor 
2012-08-30 | E-MAXD-50 | biostudies-arrayexpress
TranscriptomicsEffect of sleep restriction on the human transcriptome during extended wakefulness
In a cross balanced design human subjects were given one week of sufficient sleep and insufficient sleep (6 h per day). Following each of these conditions they were then kept awake for a day, a night and the subsequent day. During each of these periods of extended wakefulness 10 blood samples were t...
ORGANISM(S): Homo sapiens 
2013-02-27 | E-GEOD-39445 | biostudies-arrayexpress
GenomicsComprehensive analysis of orphan CpG islands identifes novel promoters with conserved DNA methylation dynamics
We report the application of single molecule-based sequencing technology in combination with CXXC affinity purifcation (CAP-seq), MBD affinity purification (MAP-seq) and chromatin immunoprecipitation (ChIP-seq) to generate reciprocal methylation and chromatin modifcation maps in human and mouse. We ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-21442 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Streptomyces coelicolor M600 bldA deletion mutant vs. wild-type M600 S.coelicolor A3(2) time series
Time-dependent gene expression patterns during development and antibiotic production on solid growth medium (SMM) comparing a M600 bldA deletion mutant with wild-type M600 of S.coelicolor A3(2). Eight time points matched in all three replicates of both wild-type and mutant were picked to span the en...
ORGANISM(S): Streptomyces coelicolor 
2008-06-05 | E-MAXD-27 | biostudies-arrayexpress
TranscriptomicsMistimed sleep disrupts circadian regulation of the human blood transcriptome
22 healthy volunteers without sleep disorders were resident in an environmental scheduling facility and participated in a forced-desynchrony protocol, in which the sleep-wake cycle and the associated fasting-feeding cycle is scheduled to a 28-hour period, of which one third (i.e. 9h 20min) is schedu...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-48113 | biostudies-arrayexpress
TranscriptomicsMouse Normal Variation
Cancer of the prostate is influenced both by genetic predisposition and environmental factors. The identification of genes capable of modulating cancer development has the potential to unravel disease heterogeneity and aid diagnostic and prevention strategies through improved understanding of gene-e...
ORGANISM(S): Mus musculus 
2007-05-31 | E-GEOD-5962 | biostudies-arrayexpress
UnknownIncreased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia?
Not available
S-EPMC5097426 | biostudies-literature
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