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ProteomicsMulti-Omic Evidence of Brain Region Specific APOE Genotype Perturbations in Alzheimer's Disease
Simultaneous extraction of proteins and lipids from human frontal cortex and cerebellum brain tissue was performed using the MPLEx procedure for both control and Alzheimer's disease patients. The isolated proteins were then reduced, alkylated, tryptically digested and evaluated with LC-IMS-MS. The p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-08 | MSV000092627 | MassIVE
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
MetabolomicsLarge-scale non-targeted plasma metabolomics in the Uppsala Longitudinal Study of Adult Men
The Uppsala Longitudinal Study of Adult Men (ULSAM) study is an ongoing, longitudinal, epidemiologic study started in 1970 and based on men born between 1920 and 1924 in Uppsala, Sweden which were invited to participate at age 50 (N=2,841) [PMID: 9484991]; 81.7% (N=2,322) participated. Individuals w...
2015-03-23 | MTBLS124 | MetaboLights
UnknownSpectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma.
Not available
S-EPMC7889847 | biostudies-literature
MetabolomicsGut Bacteroides act in a microbial consortium to cause susceptibility to severe malaria

Malaria, caused by Plasmodium species, remains a significant cause of morbidity and mortality globally. Gut bacteria can influence the severity of malaria, but the contribution of specific bacteria to the risk of severe malaria is unknown. Here, multiomics approaches demonstrate specific...

2023-09-13 | MTBLS3449 | MetaboLights
UnknownApolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy.
Not available
S-EPMC4095992 | biostudies-literature
UnknownMutational signature in colorectal cancer caused by genotoxic pks<sup>+</sup> E. coli.
Not available
S-EPMC8142898 | biostudies-literature
UnknownMicroenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.
Not available
S-EPMC5927625 | biostudies-literature
UnknownThe impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
Not available
S-EPMC8552693 | biostudies-literature
UnknownThe AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance.
Not available
S-EPMC8686208 | biostudies-literature
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