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MetabolomicsMechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes (Mouse data)
Evidence from several recent metabolomic studies suggests that increased concentrations of triacylglycerols (TAGs) with shorter (14-16 carbon atoms), saturated fatty acids are associated with insulin resistance and the risk of type 2 diabetes. Although causality cannot be inferred from association s...
2017-03-02 | MTBLS327 | MetaboLights
MetabolomicsMechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes (Human data)
Evidence from several recent metabolomic studies suggests that increased concentrations of triacylglycerols (TAGs) with shorter (14-16 carbon atoms), saturated fatty acids are associated with insulin resistance and the risk of type 2 diabetes. Although causality cannot be inferred from association s...
2015-10-05 | MTBLS162 | MetaboLights
MetabolomicsMulti-omic analysis of vaginal bacteria:host immune and metabolic interactions in early adverse pregnancy outcomes

Objective

To characterise the vaginal microbiota, mucosal metabolome and host immune response in early pregnancy and investigate its relationship with adverse pregnancy outcomes, including ectopic pregnancy, within the context of pregnancies of unknown location (PUL).

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2025-03-28 | MTBLS10098 | MetaboLights
ProteomicsOn-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions
The cyclin-dependent kinase CDK11 is an understudied kinase that has been the subject of conflicting reports regarding its function in cancer. Here, we combine genetic and pharmacological approaches to demonstrate that CDK11 is a critical regulator of cancer cell survival that is required for RNA sp...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD079783 | Pride
Kinase inhibitor Ots964 Splicing Cdk11 Cell cycle 
Genomicsgenotyped_bacterial_meningitis
This study includes 1146 samples of host genotyping data (genotyped) from Illumina Omni arrays. Samples were collected from adults (>16 yrs) patients with CSF confirmed bacterial meningitis in the Netherlands between 2006 and 2015. Metadata includes patient outcome, species of bacteria, and for 4...
EGAD00010002328 | EGA
Genomicsimputed_bacterial_meningitis
This study includes 1146 samples of host genotyping data (imputed) from Illumina Omni arrays, using https://imputation.sanger.ac.uk/ with the Haplotype Reference Consortium v1.1. Samples were collected from adults (>16 yrs) patients with CSF confirmed bacterial meningitis in the Netherlands betwe...
EGAD00010002327 | EGA
GenomicsHost genotyping data from Dutch adult bacterial meningitis patients and linked bacterial genome sequences
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. This st...
EGAS00001005993 | EGA
UnknownOn-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions.
Not available
S-EPMC12324462 | biostudies-literature
UnknownA Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Not available
S-EPMC5990023 | biostudies-literature
UnknownThe Impact of Human Immunodeficiency Virus Infection on Gut Microbiota α-Diversity: An Individual-level Meta-analysis.
Not available
S-EPMC7319268 | biostudies-literature
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